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| Antibiotic resistance analysis of ESBLs-producing Escherichia coli and Klebsiella pneumoniae in urinary tract infections in elderly patients |
| ZHANG Wenjing WANG Jiahe |
| Department of Geriatrics, Shengjing Hospital of China Medical University, Liaoning Province, Shenyang 110004, China |
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Abstract Objective To investigate the drug resistance of extended spectrum β-lactamases (ESBLs) producing Escherichia coli and Klebsiella pneumoniae in urinary tract infections in elderly patients so as to provide guidance for clinical rational use of antibiotics. Methods From January 2015 to December 2017, in Shengjing Hospital of Chinese Medical University, identification of bacteria and antibiotic susceptibility tests were performed on the strains isolated from the clean midstream urine specimens of elderly patients. ESBLs was detected by disk diffusion confirmatory test in the 1063 strains of Escherichia coli and 202 strains of Klebsiella pneumoniae. Results The detection rate of ESBLs-producing Escherichia coli and ESBLs-producing Klebsiella pneumoniae in three years was 42.24% and 38.61% respectively, and ESBLs-producing strains were more resistant to most drugs than non-ESBLs producing strains. The drug resistance rates of ESBL-producing Klebsiella pneumoniae to Amikacin, Nitrofurantoin, Piperacillin-tazobactam, Cefperazone-sulbactam (14.10%, 44.68%, 24.36%, 54.17% respectively) were higher than ESBL-producing Escherichia coli (4.23%, 6.70%, 2.46%, 15.00% respectively), and the differences were statistically significant (P < 0.05). Conlusion The drug resistance of ESBLs-producing Escherichia coli and ESBLs-producing Klebsiella pneumoniae is more severe. So the antimicrobial agents should be chosen reasonably according to the results of the drug susceptibility.
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