|
|
|
| Clinical curative effect analysis research of the autologous PRP in spinal tuberculosis bone fusion surgical treatment |
| LI Zeqing1 TANG Baoming1 TAN Jun2 ZHONG Hao1 LI Zhaowei1▲ |
1.Department of Trauma Orthopedics Surgery, Qinghai University Affiliated Hospital, Qinghai Province, Xi′ning 810001, China;
2.Department of Orthopedics & Spine Surgery, Shanghai East Hospital, Shanghai 200092, China |
|
|
|
|
Abstract Objective To discuss clinical application and curative effect of autologous platelet rich plasma (PRP) in spinal tuberculosis bone fusion surgical treatment. Methods From March 2013 to March 2016, in Qinghai University Affiliated Hospital, 32 patients with spinal tuberculosis who were all from Qinghai area were selected. Patients given autologous PRP mixture with artificial bone in spinal tuberculosis were selected as PRP group (16 cases), patients with artificial bone in spinal tuberculosis were selected as none-PRP group (16 cases). The bone transplanted fusion time, operation time, treatment time, intraoperative blood loss, postoperative Oswestry index (ODI), VAS score, CRP, ESR after 1 week to 2 months, complication incidence of patients were recorded and analyzed. Results All the patients' spinal tuberculosis in PRP group and none-PRP group were cured. The bone fusion time, average operation time the average time of treatment, postoperative 1 weeks to 2 months hs-CRP, ESR value, and complication rate in PRP group were shorter or lower than those in none-PRP group, ODI scores in PRP group was higher than that in none-PRP group, the differences were statistically significant (P < 0.05). The amount of bleeding and postoperative pain VAS score (not including donor) in two groups were compared, the differences were not statistically significant (P > 0.05). Conclusion Autologous PRP and artificial bone mixture compares with ilium in spinal tuberculosis after grafting bone fusion has obvious advantages. Its application not only shortens the operation time, but also effectively avoid the donor bone pain and other complications. Most notably, the PRP-artificial bone can substantially shorten the time of bone graft fusion and provide an effective and reasonable treatment for spinal tuberculosis.
|
|
|
|
|
|
[1] 黎洪棉，高建华，鲁峰，等.BrdⅡ标记家兔脂肪组织来源干细胞的体外研究[J].中国修复重建外科杂志，2008，22（1）：97-101.
[2] Dicker A，Le Blanc K，Astrom G，et al. Functional studies of mesenchymal stem cells derived from adult human adipose tissue [J]. Exp Cell Res，2005，308（2）：283-290.
[3] De Girolamo L，Sartori MF，Albisetti W，et al. Osteogenic diff erentiation of human adipose-derived stem cells：comparison of two diff erentinductive media [J]. J Tissue Eng Regen Med，2007，1（2）：154-157.
[4] De Ugarte DA，Morizono K，Elbarbary A，et al. Comparison of multilineage cells from human adipose tissue and bone marrow [J]. Cells Tissues Organs，2003，174（3）：101-109.
[5] 张端珍，盖鲁粤，刘宏伟.脂肪干细胞与间充质干细胞体外诱导分化为心肌细胞的差别[J].生理学报，2008，60（3）：35-41.
[6] Cao Y，Sun Z，Liao L，et al. Human adipose tissue-derived stem cells diff erentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo [J]. Biochem Biophys Res Commun，2005，332（2）：370-379.
[7] Vermette M，Trottier V，Ménard V，et al. Production of a new tissue engineered adipose substitute from human adipose-derived stromal cells [J]. Biomaterials，2007，28（18）：2850-2860.
[8] Kingham PJ，Kalbermatten DF，Mahay D，et al. Adipose-derived stem cells diff erentiate into a Schwann cell phenotype and promote neurite outgrowth in vitro [J]. Exp Neurol，2007，207（2）：267-274.
[9] Banas A，Teratani T，Yamamoto Y，et al. Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes [J]. Hepatology，2007，46（1）：219-228.
[10] Riley G. Chronic tendon pathology molecular basis and therapeutic implications [J]. Expert Rev Mol Med，2005， 7（5）：1-25.
[11] Almekinders LC. Etiology，diagnosis，and treatment of tendonitis：an analysis of the literature [J]. Med Sci Sports Exerc，1998，30（8）：1183-1190.
[12] Castillo TN，Pouliot MA，Kim HJ，et al. Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems [J]. Am J Sports Med，2011，39（2）：266-271.
[13] 陈学英，李宝兴，李靖，等.异种骨移植材料制备及其骨诱导活性实验研究[J].中国修复重建外科杂志，2009， 23（3）：362-365.
[14] 李明，张长青，袁霆，等.富血小板血浆制备套装的评估研究[J].中国修复重建外科杂志，2011，25（1）：112-116.
[15] Landesberg R，Roy M，Glickman RS. Quantification of growth factor levels using a simplified method of platelet-rich plasma gel preparation [J]. J Oral Maxillofac Surg，2000，58（3）：297-300.
[16] 毕树雄，戴勉戎，汤亭亭.IL-4与IL-10联合诱导异种骨移植免疫耐受的实验研究[J].中国矫形外科杂志，2005， 3（15）：1174-1178.
[17] 孙涛，栾景杰，高复峪，等.富血小板血浆对四肢粉碎性骨折患者骨折愈合的影响[J].中国医药导报，2016，13（36）：117-120. |
|
|
|
