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| Analysis on distribution, drug resistance, and influence factors of fungal infection after colorectal cancer operation |
| SHEN Bingzheng1 CHEN Zhiming1 LI Hua1 PEI Xiaoping1 GAO Xiang2 YU Yan3▲ |
1.Department of Pharmacy, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China;
2.Department of Central Laboratory, Renmin Hospital of Wuhan Universety, Hubei Province, Wuhan 430060, China;
3.Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, Wuhan 430030, China |
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Abstract Objective To explore the distribution of pathogenic fungus, drug resistance, and influence factors of fungal infection after colorectal cancer operation. Methods 46 cases of fungal infection patients in Department of Gastrointestinal Surgery after colorectal cancer operation from January 2014 to June 2016 were selected. The identification, distribution, drug resistance and influence factors of pathogenic fungus isolated form patients' blood, urine, sputum and secretions in the surgical site were analyzed. Results Pathogenic fungus isolated mainly from the secretion of surgical site and blood. The isolation rates of Candida albicans, Candida parapsilosis, Candida glabrata and Candida krusei were high, the isolation rate was 28.3%, 21.7%, 13.0% and 10.9% respectively. The results of antifungal-drug sensitive experiment showed that the pathogenic fungus displayed different degrees of resistance against antifungal drugs. Pathogenic fungus presented higher resistant rates against Fluconazole, Ketoconazole and Econazole (resistant rate more than 20%), but sensitive against 5-fluorine cytosine, Amphotericin B and Voriconazole (sensitive rate more than 90%). The results of single factor χ2 test showed that operation time, age, and basal metabolic disorder were the important influence factors of fungal infection after colorectal cancer operation (P < 0.05). Conclusion Clinical medical staff should pay much more attention to patients with related influence factors and prevent fungal infection after colorectal cancer operation. If fungal infection has occurred, appropriate antifungal drugs should be selected according to the results of drug sensitive experiment.
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