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| Effects of Chaishi Tuire Granules on epidemic encephalitis B virus CQ11-66 |
| LIU Zhiyong1 MENG Yi1 CHANG Xuehui1 GUO Jian1 QIAO Mingliang1 ZHAO Li'na2 |
1.Department of Encephalopathy, He'nan Traditional Chinese Medicine Hospital, He'nan Province, Zhengzhou 450002, China;
2.Department of Traditional Chinese Medicine, Zhengzhou Children's Hospital, He'nan Province, Zhengzhou 450053, China |
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Abstract Objective To investigate the effects of Chaishi Tuire Granules on epidemic encephalitis B virus CQ11-66. Methods One hundred and fifty patients with epidemic encephalitis B hospitalized in He'nan Traditional Chinese Medicine Hospital from May 2015 to December 2016 were selected and divided into two groups by random number table method, with 75 cases in each group. The control group was treated with routine comprehensive treatment, on basis of control group, the observation group was added with Chaishi Tuire Granules. Both groups were treated for 15 days. After treatment, the clinical efficacy and symptom improvement time of the two groups were observed, the hospital stay and the contents of serum neuron-specific enolase (NSE), lipid peroxidase (LPO), interleukin-2 (IL-2) before and after treatment between the two groups were compared. Results The cure rate in the observation group was significantly higher than that in the control group, the difference was statistically significant (P ＜ 0.05), the total effective rate in the observation group was higher than that in the control group, but the difference was not statistically significant (P ＞ 0.05). The time of body temperature returned to normal, time of intelligence returned to normal, and the relief time of headache, vomiting, convulsions in the observation group was all shorter than those of control group, the differences were all statistically significant (P ＜ 0.05). The average hospital stay of observation group was shorter than that of control group, the difference was statistically significant (P ＜ 0.05). After treatment, the contents of serum NSE, LPO in the two groups were all lower than those before treatment, the contents of IL-2 were higher than those before treatment, the differences were all statistically significant (P ＜ 0.05). But there were no statistically significant differences of the contents of serum NSE, LPO, IL-2 after treatment between the two groups (P ＞ 0.05). Conclusion Chaishi Tuire Granules has obvious therapeutic effect for epidemic encephalitis B virus CQ11-66, which can obviously shorten hospital stay, speed up the improvement of symptoms, relieve the pain of patients effectively, it is worthy of extensive promotion.
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