不同麻醉方法对妇科手术患者免疫功能的影响

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Abstract Objective To observe and analyze the effects of different anesthesia methods on immune function in patients with gynecological surgery. Methods From February 2014 to December 2015, in Shiyan Maternal and Child Health-Care Hospital, 156 patients underwent gynecological surgery were selected, they were divided into three groups by the anesthesia method, group A was given Dexmedetomidine intravenous infusion combined with Sevoflurane inhalation anesthesia, group B was given Sevoflurane inhalation anesthesia, group C was given Propofol combined with Sufentanil anesthesia. The changes of SBP, DBP, HR, RR, SpO2, peripheral blood T lymphocyte subsets and inflammatory cytokines of all patients were observed at before anesthesia (T0), after surgrey 2 h (T1),after surgrey 6 h (T2), after surgrey 12 h (T3), after surgrey 1 d (T4), after surgrey 3 d (T5), after surgrey 7 h (T6). Results The levels of SBP at T1, T2, T3, DBP, RR at T1, T2, TNF-α at T1, T6, IL-6, IL-8 at T1-T6, CD3+ at T1, CD4+ at T1, T2 of group A were compared with those at T0, the differences were statistically significant (P < 0.05). The levels of SBP at T1, T2, T3, RR at T1, T2, TNF-α at T1, T2, T5, T6, IL-6, IL-8 at T1-T6, CD3+ at T1, CD4+ at T1, T2, T3 of group B were compared with those at T0, the differences were statistically significant (P < 0.05). The levels of SBP at T1, T2, T3, TNF-α at T1, T4-T6, IL-1β at T6, IL-6, IL-8 at T1-T6, CD3+, CD4+ at T1 of group C were compared with those at T0, the differences were statistically significant (P < 0.05). The levels of IL-6 at T1-T6, IL-8 at T1, T5, T6 of group B, the levels of TNF-α at T5, IL-6，IL-8 at T1-T6 of group C were compared with those at the same time points of group A, the differences were statistically significant (P < 0.05). The levels of IL-6, IL-8 at T1-T6 of group C were compared with those at the same time points of group B, the differences were statistically significant (P < 0.05). Conclusion The combination of Dexmedetomidine and Sevoflurane inhalation has a transient inhibitory effect on the immune function of gynecological patients. Compared with other anesthesia methods, the immune function recovered more quickly after surgery, which is anesthesia for gynecological patients ideal method, it is worth to popularize and apply in clinic.

Key words： Immune function Gynecological surgery Anesthesia Influences

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	CHEN Xinyan WANG Lei NIU Shikun FANG Xianjie

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CHEN Xinyan WANG Lei NIU Shikun FANG Xianjie. Effects of different anesthesia methods on immune function in patients with gynecological surgery[J]. 中国医药导报, 2017, 14(16): 59-62.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I16/59

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