赤芍乙醇提取物和水提取物抗病毒研究

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Abstract Objective To investigate the antiviral activity of ethanol extract and water extract of Paeoniae Radix Rubra. Methods Combining with cytopathic effect (CPE) method and CCK-8, taking therapeutic index (TI) as index, the prevention, direct killing and penetration inhibition effects of ethanol extract and water extract of Paeoniae Radix Rubra for respiratory syncytial virus (RSV), herpes simplex virus (HSV-1), Coxsackie virus (COX-B5), hand, foot and mouth virus (EV71) were researched. Results The ethanol extract and water extract of Paeoniae Radix Rubra had no prevention and penetration inhibition effects for RSV, HSV-1, COX-B5, EV71, which had no direct killing effects for EV71 and had direct killing effects for RSV, HSV-1, COX-B5, among which, the water extract had better direct killing effects for RSV and COX-B5, the TI value was 15.034 and 13.076 respectively. 75% ethanol extract of Paeoniae Radix Rubra had good direct killing effect for HSV-1, the TI value was 10.944, all positive control drugs had effects for the four kinds of virus, among which, the TI values of Ribavirin for the direct killing, prevention and penetration inhibition effects of RSV were 19.760, 16.760, 18.028 respectively, which were 17.482, 15.516, 16.568 for COX-B5, 43.158, 24.296, 22.162 for EV71. The TI values of Acyclovir for the direct killing, prevention and penetration inhibition effects of HSV-1 were 23.432, 10.922, 23.417 respectively. Conclusion The ethanol extract and water extract of Paeoniae Radix Rubra has direct killing effects for RSV, HSV-1, COX-B5, has no direct killing effects for EV71, has no prevention and penetration inhibition effects for four kinds of virus, while the positive control drugs have direct killing, prevention and penetration inhibition effects for the four kinds of virus.

Key words： Paeoniae Radix Rubra Antiviral Respiratory syncytial virus Herpes simplex virus Coxsackie virus

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	LIU Xiangwen HOU Lin ZHANG Chenghua SUN Chunyong LIU Jin′an TIAN Jingzhen

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LIU Xiangwen HOU Lin ZHANG Chenghua SUN Chunyong LIU Jin′an TIAN Jingzhen. Study on the antiviral activity of ethanol extract and water extract of Paeoniae Radix Rubra[J]. 中国医药导报, 2017, 14(16): 4-7.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I16/4

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