|
|
|
| Advance in research on the effects of extracellular vesicles on the biological characteristics of tumor |
| HE Ling1 ZHANG Xiaoyan2 YANG Yazhi3 LI Jian3▲ |
1.Clinical Department, Jiangxi Health Vocational College, Jiangxi Province, Nanchang 330052, China;
2.Medical College of Nanchang University, Jiangxi Province, Nanchang 330006, China;
3.Key Blood Laboratory, the Second Affiliated Hospital of Nanchang University, Jiangxi Province, Nanchang 330052, China |
|
|
|
Abstract Tumor growth, invasion and metastasis depend on the "cross-talk" between tumor cells and stromal cells in their microenvironment, which mainly involves the secretion of soluble factors of these two kinds of cells, the release of membrane-tomont particles and the direct contact between cells. These vesicles are known as extracellular vesicles (EVSs), and tumor cells secrete more EVSs than normal cells, which separate proteins, DNA, RNA, and other "contents" into the body through both escrt-dependent and escrt-independent pathways. These "contents" facilitate the transmission of information between tumor cells and stromal cells, thus supporting tumor angiogenesis, invasion and metastasis, drug resistance, and malignant characterization of tumor cells.
|
|
|
|
|
|
[1] Henne WM，Buchkovich NJ，Emr SD. The ESCRT pathway [J]. Dev Cell，2011，21（1）：77-91.
[2] Wang Q，Lu Q. Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling [J]. Nat Commun，2017，8（1）：709.
[3] Trajkovic K，Hsu C，Chiantia S，et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes [J]. Science，2008，319（5867）：1244-1247.
[4] van Niel G，Wubbolts R，Broeke T，et al. Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination [J]. Immunity，2006，25（6）：885-894.
[5] Ratajczak J，Miekus K，Kucia M，et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors：EVsidence for horizontal transfer of mRNA and protein delivery [J]. Leukemia，2006，20（5）：847-856.
[6] Valadi H，Ekstrom K，Bossios A，et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells [J]. Nat Cell Biology，2007，9（6）：654-659.
[7] Pegtel DM，Cosmopoulos K，Thorley DA，et al. Functional delivery of viral miRNAs via exosomes [J]. Proc Natl Acad Sci USA，2010，107（14）：6328-6333.
[8] Thomou T，Mori MA，Dreyfuss JM，et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues [J]. Nature，2017，542（7642）：450-455.
[9] Sansone P，Savini C，Kurelac I，et al. Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer [J]. Cell Reports，2017，114（43）：E9066-E9075.
[10] Takahashi A，Okada R，Nagao K，et al. Exosomes maintain cellular homeostasis by excreting harmful DNA from cells [J]. Nat Commun，2017，8：15 287.
[11] Takasugi M，Okada R，Takahashi A，et al. Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 [J]. Nat Commun，2017，8：15 729.
[12] Imjeti NS， Menck K，Egea-Jimenez AL，et al. Syntenin mediates SRC function in exosomal cell-to-cell communication [J]. Nat Commun，2017，114（47）：12 495-12 500.
[13] Wei Y， Wang D， Jin F，et al. Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein [J]. Nat Commun，2017，8：140-141.
[14] Li L，Li C，Wang S，et al. Exosomes derived from hypoxic oral squamous cell carcinoma cells deliver miR-21 to normoxic cells to elicit a prometastatic phenotype [J]. Cancer Res，2016，76（7）：1770-1780.
[15] Imjeti S，Menck K，Jimenez A，et al. Syntenin mediates SRC function in exosomal cell-to-cell communication [J]. Cancer Res，2017，114（47）：12 495-12 500.
[16] Nabet BY，Qiu Y，Shabason JE，et al. Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer [J]. Cell，2017，170（2）：352-366.
[17] Webber J，Spary L，Sanders A，et al. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes [J]. Oncogene，2015，34（3）：290-302.
[18] Baglio S，Lagerweij T，Pérez-Lanzón M，et al. Blocking tumor-educated MSC paracrine activity halts osteosarcoma progression Clinical [J]. Cancer Res，2017，23（14）：3721-3733.
[19] Feng Q，Zhang C，Lum D，et al. A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis [J]. Nat Commun，2017，8：14 450.
[20] Godlewski J，Ferrer-Luna R，Rooj AK，et al. Mine MicroRNA signatures and molecular subtypes of glioblastoma：the role of extracellular transfer Stem [J]. Stem Cell Reports，2017，8（6）：1497-1505.
[21] Zhang L，Zhang S，Yao J，et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth [J]. Nature，2015，527（7576）：100-104.
[22] Godlewski J，Ferrer-Luna R，Rooj AK，et al. Mine MicroRNA signatures and molecular subtypes of glioblastoma：the role of extracellular transfer [J]. Stem Cell Reports，2017，8（6）：1497-1505.
[23] Melo S，Sugimoto H，O′Connell JT，et al. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis [J]. Cancer Cell，2014，26（5）：707-721. |
|
|
|
