碳青霉烯类药物使用强度与常见革兰阴性杆菌耐药相关性

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Abstract Objective To analyze the changes of defined daily doses of carbapenems antibacterial agents and the changes of main gram negative bacilli of carbapenems resistant drugs, and the relationship between them. Methods The use conditions of carbapenems antibacterial agents in Yongkang First People′s Hospital of Zhejiang Province (“our hospital” for short) from January 2014 to January 2017 were collected by hospital information system, and the resistant rate of gram negative bacilli for carbapenems was calculated by WHONET 5.4 software, and the correlation analysis was performed. Results The amount of carbapenems antibacterial agents in our hospital was increasing year by year, among which, the used number, consumption sum and defined daily doses of Meropenem increased rapidly. The total bacteria inspection results of our hospital were increased year by year, among the several major gram negative bacilli, the growth rate of Acinetobacter baumannii detection among 4 years had highly statistically significant difference (P ＜ 0.01), as well as, Acinetobacter baumannii had a significant growth resistance to Meropenem and Imipenem/Cilastatin Sodium (P ＜ 0.05), Klebsiella pneumonia had a significant growth resistance to Meropenem (P ＜ 0.01). Furthermore, the resistance rate of Acinetobacter baumannii and Klebsiella pneumoniae for Meropenem was positively correlated with the defined daily doses of Meropenem (P ＜ 0.05). Conclusion Along with the application of carbapenems antibacterial agents and the increased test number of main gram negative bacilli year by year, there is some correlation between defined daily doses of carbapenems and the increase of some drug-resistance bacteria. It is necessary to strengthen the management of carbapenems, and control the production of drug-resistant bacteria.

Key words： Carbapenems Defined daily doses Drug resistance rate Correlation

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	SHEN Xiaohong1 LYU Meiyan1 WANG Lizhi1 XU Xiangwei2

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SHEN Xiaohong1 LYU Meiyan1 WANG Lizhi1 XU Xiangwei2. Correlation between drug use intensity of carbopenems and drug resistance of common gram negative bacilli[J]. 中国医药导报, 2019, 16(18): 109-112.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I18/109

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