外周血T细胞亚群与突发性耳聋发病的关系

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Abstract Objective To investigate the relationship between peripheral blood T cell subsets and onset and prognosis of sudden deafness. Methods Seventy-six patients with sudden deafness admitted to Ezhou Central Hospital from August 2016 to August 2018 were selected as the study group. Another 60 healthy people who underwent health examination during the same period were selected as the control group. The patients in the study group received routine treatment for 10 d. The level of peripheral blood T cell subsets of the two groups was detected and compared. According to the curative effect, the study group were divided into effective group (54 cases) and ineffective group (22 cases), the level of peripheral blood T cell subsets of the two groups was compared. According to the imbalance of peripheral blood T cell subsets of the study group, the patients were divided into normal group (27 cases) and imbalance group (49 cases), the effective rate of the two groups was compared. Results Compared with the control group, CD3+, CD4+ and CD4+/CD8+ in peripheral blood of the study group before treatment were significantly lower, while CD8+ was significantly higher, the differences were statistically significant (P ＜ 0.05). The peripheral blood CD4+ and CD4+/CD8+ in the study group were significantly increased and CD8+ was significantly decreased after treatment compared with those before treatment, the differences were statistically significant (P ＜ 0.05). Compared with the control group, there was no significant difference in CD3+ and CD4+ in peripheral blood after treatment in the study group (P ＞ 0.05), but CD4+/CD8+ was significantly lower and CD8+ was significantly higher in the study group (P ＜ 0.05). Compared with the effective group, CD3+, CD4+ and CD4+/CD8+ in the ineffective group were significantly lower, while CD8+ was significantly higher, the differences were statistically significant (P ＜ 0.05). The effective rate of treatment in the normal group (88.89%) was significantly higher than that in the imbalance group (61.22%) (P ＜ 0.05). Conclusion The onset of sudden deafness is related to the imbalance of peripheral blood T cell subsets. Immune dysfunction may affect the hearing recovery of sudden deafness patients.

Key words： Peripheral blood T cell subsets Sudden deafness Onset Prognosis

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	LI Wei1 SHE Wensheng1 WU Xinyu1 HU Xian2

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LI Wei1 SHE Wensheng1 WU Xinyu1 HU Xian2. Relationship between peripheral blood T cell subsets and onset of sudden deafness[J]. 中国医药导报, 2019, 16(18): 106-108,116.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I18/106

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