|
|
|
| Relationship between dioxins exposure and endometriosis |
| LIU Juan CHEN Canming XU Yang ZHANG Wei ZHANG Lei |
| Department of Obstetrics and Gynecology, Maternal and Child Health Hospital of Yangzhou, Jiangsu Province, Yangzhou 225000, China |
|
|
|
Abstract Objective To investigate the relationship between dioxins exposure and endometriosis, and to provide theoretical basis for the prevention and treatment of disease. Methods From December 2016 to January 2019, 50 patients with pelvic pack block in Maternal and Child Health Hospital of Yangzhou were selected, and 25 patients with endometriosis confirmed by pathology after surgery were set as the case group, 25 patients without endometriosis were set as control group. The correlation between dioxins exposure and endometriosis was analyzed by means of homemade questionnaire survey, and blood specimens from patients were collected to detect dioxin levels of blood by Soxhlet extraction chromatography column purification-isotope dilution HRGC-HRMS, and those results were compared between the two groups. Results The proportion of people who cook regularly in case group were significantly higher than that in control group, the proportion of people who often eat duck and quail eggs in case group were lower than that in control group, the differences were statistically significant (P < 0.05). The contents and the toxic equivalence of dioxins such as Polychlorinated Dibenzofura, 2,3,7,8-Tetrachlorodibenzofuran (2,3,7,8-T4CDF), 1,2,3,7,8-Pentachlorodibenzofuran (1,2,3,7,8-P5CDF) and 2,3,4,7,8-Pentachlorodibenzofuran (2,3,4,7,8-P5CDF) in the blood of case group were significantly higher than those of control group, the differences were statistically significant (P < 0.05). Conclusion The association exits between dioxins exposure and endometriosis, and cooking regularly might be a risk factor for exposure dioxins for endometriosis.
|
|
|
|
|
|
[1] 李雷，冷金花.子宫内膜异位症相关生活质量的研究进展[J].中华医学杂志，2017，97（45）：3593-3596.
[2] Smarr MM，Kannan K. Endocrine disrupting chemicals and endometriosis [J]. Fertil Steril，2016，106（4）：959-966.
[3] Porpora MG，Ingelido AM，di Domenico A，et al. Increased levels of polychlorobiphenyls in Italian women with endometriosis [J]. Chemosphere，2006，63（8）：1361-1367.
[4] De Felip E，Porpora MG，di Domenico A，et al. Dioxin-like compounds and endometriosis：a study on Italian and Belgian women of reproductive age [J]. Toxicol Lett，2004， 150（2）：203-209.
[5] Caroline S，Hoffman MSPH，Chanley M. Endometriosis among women exposed to polybrominated biphenyls [J]. Ann Epidemiol，2007，17（7）：503-510.
[6] Rier SE，Martin DC，Bowman RE，et al. Endometriosis in rhesus monkeys （Macaca mulatta） following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin [J]. Fundam Appl Toxicol，1993，21（4）：433-441.
[7] 刘娟，任慕兰.二噁英对小鼠异位子宫内膜中IL-1β表达的影响[J].中国妇幼健康研究，2011，22（2）：162-164.
[8] Wen X，Xiong Y，Qu X，et al. The risk of endometriosis after exposure to endocrine-disrupting chemicals：a meta-analysis of 30 epidemiology studies [J]. Gynecol Endocrinol，2019，23：1-6.
[9] 陈苏，周子寒，阳晓敏，等.环境内分泌干扰物暴露与子宫内膜异位症[J].现代预防医学，2018，45（22）：4058-4061.
[10] Foster WG. Endocrine toxicants including 2,3,7,8-terachlorodibenzo-p-dioxin （TCDD） and dioxin-like chemicalsand endometriosis：is there a link [J]. J Toxicol Environ Health B Crit Rev，2008，11（3/4）：177-187.
[11] Cano-Sancho G，Ploteau S，Matta K，et al. Human epidemiological evidence about the associations between exposure to organochlorinechemicals and endometriosis：systematic review and meta-analysis [J]. Environ Int，2019，123：209-223.
[12] 陈天金，李耘.澳大利亚二嗯英膳食暴露评估及其对我国的启示[J].环境与健康杂志，2008，25（12）： 1124-1127.
[13] Porpora MG，Medda E，Abballe A，et al. Endometriosis and organochlorinated environmental pollutants：a case-control study on Italian women of reproductive age [J]. Environ Health Perspect，2009，117（7）：1070-1075.
[14] Mayani A，Barel S，Soback S，et al. Dioxin concentrations in women with endometriosis [J]. Hum Reprod，1997，12（2）：373-375.
[15] Culley L，Law C，Hudson N，et al. The social and psychological impact of endometriosis on women′s lives：a critical narrative review [J]. Hum Reprod Update，2013，19（6）：625-639.
[16] Cai LY，Izumi S，Suzuki T，et al. Dioxins in ascites and serum of women with endometriosis：a pilot study [J]. Hum Reprod，2011，26（1）：117-126.
[17] Yao M，Hu T. Polychlorinated biphenyls and its potential role in endometriosis [J]. Environ Pollut，2017，229：837-845.
[18] Simsa P，Mihalyi A，Schoeters G，et al. Increased exposure to dioxin-like compounds is associated with endometriosis in a case-control study in women [J]. Reprod Biomed Online，2010，20（5）：681-688.
[19] Ploteau S，Antignac JP，Volteau C，et al. Distribution of persistent organic pollutants in serum，omental，and parietal adipose tissue of Frenchwomen with deep infiltrating endometriosis and circulating versus stored ratio as new marker of exposure [J]. Environ Int，2016，97：125-136.
[20] Ploteau S，Cano-Sancho G，Volteau C，et al. Associations between internal exposure levels of persistent organic pollutants in adipose tissue and deep infiltrating endometriosis with or without concurrent ovarian endometrioma [J]. Environ Int，2017，108：195-203.
[21] Heilier JF，Nackers F，Verougstraete V，et al. Increased dioxin-like compounds in the serum of women with peritoneal endometriosis and deep endometriotic （adenomyotic） nodules [J]. Fertil Steril，2005，84（2）：305-312.
[22] Niska AS，Needham LL，et al. Serum dioxins，polychlorinated biphenyls，and endometriosis：a case-control study in Atlanta [J].Chemosphere，2009，74（7）：944-949.
[23] Xin X，Jin Z，Gu H，et al. Association between glutathione S-transferase M1/T1 gene polymorphisms and susceptibility to endometriosis：a systematic review and meta-analysis [J]. Exp The Med，2016，11（5）：1633-1646. |
|
|
|
