|
|
|
| A randomized control study on preventing postpartum hemorrhage with three regimens in high risk pregnancy women during cesarean section |
| Nurgul·Yusuyun1 Dildar·Yusan1 Guzainuer·Maimaitituerxun1 Mayila·Maimaiti1 Minavar·Amaiti1 Riyangul·Tohuti1 Baharguli·Abulati1 CHEN Xing2▲ |
1.Department of Obstetrics, Kashgar Prefecture Second People′s Hospital, Xinjiang Uygur Autonomous Region, Kashgar 844000, China,
2.Department of Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai 200011, China |
|
|
|
Abstract Objective To study the preventive effect of three uterine contraction regimens in pregnancy women with postpartum hemorrhage risk factor during cesarean section. Methods From July 2017 to May 2018, 119 pregnancy women who with postpartum hemorrhage risk and undergoing cesarean section in Kashgar Prefecture Second People′s Hospital of Xinjiang Uygur Autonomous Region were selected, and they were divided into group A (Oxytocin), group B (Oxytocin combined with Kaprostatin Tromethamine), and group C (Oxytocin combined with Misoprostol) according to the different drug regimen, 39 cases in group A, 40 cases in group B, and 40 cases in group C. The amount of blood loss in 2 h and 2-24 h after operation and failure ratio were recorded independently. Results Blood loss of group B was significantly less than group A 2 h and 2-24 h after operation (P < 0.05). The blood loss of group C 2 h after operation has no significant difference with group A (P > 0.05), but was significantly less than group A 2-24 h after operation (P < 0.05). Compared with group C, group B had less blood loss 2 h after operation, but had no significant difference during 2-24 h after operation (P > 0.05). The failure ratio among three groups had no significant difference (P > 0.05). Conclusion The regimen of Oxytocin combined with Kaprostatin Tromethamine can effectively reduce blood loss in pregnancy women with postpartum hemorrhage risk after cesarean section. The regimen of Oxytocin combined with Misoprostol can reduce blood loss during 2-24 h after operation. All three regimens have definitely failed ratio.
|
|
|
|
|
|
| Cite this article: |
|
Nurgul·Yusuyun1 Dildar·Yusan1 Guzainuer·Maimaitituerxun1 Mayila·Maimaiti1 Minavar·Amaiti1 Riyangul·Tohuti1 Baharguli·Abulati1 CHEN Xing2▲. A randomized control study on preventing postpartum hemorrhage with three regimens in high risk pregnancy women during cesarean section[J]. 中国医药导报, 2019, 16(18): 81-84.
|
|
|
|
| URL: |
| http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I18/81 |
[1] 王绮，肖小敏．基层医院产后出血的预防和处理[J/CD].中华产科急救电子杂志，2014，3（4）：263-266．
[2] 李可瑜，唐璇霓，温慧霞，等.产后出血的原因分析及治疗对策研究[J].中国实用医药，2018，13（20）：74-76.
[3] Moucheraud C，Gass J，Lipsitz S，et al. Bedside Availability of Prepared Oxytocin and Rapid Administration After Delivery to Prevent Postpartum Hemorrhage：An Observational Study in Karnataka， India [J]. Glob Health Sci Pract，2015，3（2）：300-304.
[4] Rajan PV，Wing DA. Postpartum Hemorrhage：Evidence-based-medical interventions for prevention and treatment [J]. Clin Obstet Gynecol，2010，53（1）：165-181．
[5] Mercede S，Edwin C. An update on the risk factors for and management of obstetric haemorrhage [J]. Women′s Health，2017，13（2）：34-40.
[6] Smit M，Chan KL，Middeldorp JM，et al. Postpartum haemorrhage in midwifery care in the Netherlands：validation of quality indicators for midwifery guidelines [J]. BMC Pregnancy Childbirth，2014，14：397-402.
[7] Nelissen EJ，Mduma E， Ersdal HL，et al. Maternal near miss and mortality in a rural referral hospital in northern Tanzania：a cross-sectional study [J]. BMC Pregnancy Childbirth，2013，13：141-150.
[8] 钟柳英，陈敦金，纪艳洁，等．麦角新碱预防高危孕产妇剖宫产出血的疗效观察[J/CD].中华产科急救电子杂志，2018，7（3）：180-184．
[9] 朱方玉，漆洪波.ACOG实践简报“产后出血（2017版）”解读.中国实用妇科与产科杂志[J]，2018，34（6）：623-627.
[10] 杨继，张慧.米索前列醇不同给药方式联合缩宫素预防产后出血的临床研究[J].疑难病杂志，2011，10（12）：907-908.
[11] 宋茂芳，柴建华，洪程程，等.米索前列醇联合缩宫素预防自然分娩产后出血有效性的Meta分析[J].四川医学，2017，38（3）：319-323.
[12] 汪丹，秦利．欣母沛治疗产后出血的临床研究[J].国外医学·妇幼保健分册，2004，16（2）：124-125．
[13] 应豪，王德芬，陈如钧．卡前列素氨丁三醇在中央性前置胎盘剖宫产时应用时间的探讨及疗效[Ｊ].中国新药与临床杂志，2005，24（3）：223-224.
[14] 王晓怡，王子莲，钟梅，等．国产卡前列素氨丁三醇防治高危产妇剖宫产出血的疗效观察[J/CD].中华产科急救电子杂志，2014，3（2）：127-131．
[15] 姚永畅.卡前列腺素氨丁三醇应用时机对宫缩乏力性产后出血的防治效果观察[J].中国计划生育学杂志，2017， 25（10）：680-684.
[16] 上海产后出血研究协作组.上海市剖宫产出血计量研究[J].上海医学，2001，24（6）：332-335.
[17] 周艺.不同用药方案在预防产后出血中的疗效比较[J].湖南师范大学学报：医学版，2017，14（2）：167-170.
[18] 任小平.产后出血的药物治疗进展[J].临床医药实践，2018，27（11）：860-862.
[19] 刘兴会，陈锰.基于大数据的产后出血临床处理[J].中国实用妇科与产科杂志，2018，34（1）：33-37.
[20] 刘正丽，张志容，罗华梅，等.产后出血止血方法选择及止血失败原因分析[J].医学综述，2015，21（8）：1528-1530. |
|
|
|
