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Advance in pharmacological studies of Polygonati Rhizoma and its extract based on neurovascular unit |
CHAO Bin HUANG Shijing |
Research and Development Center of Traditional Chinese Medicine, Guang′anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China |
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Abstract As the basic unit of structure and function of nervous system, neurovascular unit is an important aspect in the research of modern pharmacology of nervous system. In order to further understand the pharmacological effects of Polygonati Rhizoma and its extract on neurovascular unit, articles about the pharmacological effects of Polygonati Rhizoma on neurovascular unit are analyzed comprehensively. It is found that Polygonati Rhizoma and its extract affect the structure and function of the nervous system by regulating the apoptosis of nerve cells, anti-oxidation, improving the microstructure of each part of neurovascular unit and inducing the secretion of growth factors. So Polygonati Rhizoma may have the capacity for maintaining the stalibity of microenvironment of brain. Therefore, the application of Polygonati Rhizoma and its extracts may play a potential role in the treatment of nervous system diseases.
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[1] 张磊,曾高峰,宗少晖,等.黄精多糖防治绝经后骨质疏松症的分子机制[J].中国组织工程研究,2018,22(4):493-498.
[2] 何俊婷,曹爱兰,赵新礼,等.不同基原与产地的黄精对比研究[J].中国药业,2017,26(19):23-26.
[3] 姜程曦,张铁军,陈常青,等.黄精的研究进展及其质量标志物的预测分析[J].中草药,2017,48(1):1-16.
[4] 胡国柱,聂荣庆,肖移生.黄精多糖对新生大鼠大脑皮层神经细胞缺氧性凋亡的影响[J].中药药理与临床,2005, 21(4):37-39.
[5] 赵文莉,赵晔,Yiider Tseng.黄精药理作用研究进展[J].中草药,2018,49(18):4439-4445.
[6] 方欢乐,李晓明,李秋全,等.黄精多糖的提取及抗氧化作用的研究[J].生物化工,2018,4(3):11-12,15.
[7] 丁安荣,李淑莉.黄精等六种补益药对小鼠红细胞膜Na+-K+-ATP酶活性的影响[J].中成药,1990,12(9):28.
[8] 肖移生.缺血/缺氧性神经细胞凋亡与中药黄精药理作用研究进展[J].江西医学院学报,2005,45(2):103-104, 107.
[9] 衡银雪,刘丹丹,边凤霞,等.黄精多糖抗衰老作用及其食品应用研究进展[J].重庆工商大学学报:自然科学版,2017,34(6):111-117.
[10] Zong S,Zeng G,Zou B,et al. Effects of Polygonatum sibiricum polysaccharide on the osteogenic differentiation of bone mesenchymal stem cells in mice [J]. Int J Clin Exp Pathol,2015,8(6):6169-6180.
[11] Zhang H,Cao Y,Chen L,et al. A polysaccharide from Polygonatum sibiricum attenuates amyloid-β-induced neurotoxicity in PC12 cells [J]. Carbohydr Polym,2015, 117:879-886.
[12] 易玉新,吴石星,叶茂盛,等.Aβ1-42海马注射对大鼠海马细胞的影响及黄精多糖的干预研究[J].中南大学学报:医学版,2014,39(4):244-348.
[13] 易玉新,吴石星,叶茂盛.Aβ1-42 海马注射致大鼠海马细胞凋亡作用及黄精多糖干预的作用[J].中国老年病学杂志,2015,35(4):1044-1045.
[14] 李微,彭锐,唐理斌,等.滇黄精对大鼠脑缺血再灌注损伤神经元的作用[J].大理学院学报:自然科学,2006,5(10):19-21.
[15] 王玉勤,于晓婷,吴晓岚,等.黄精多糖对力竭小鼠脑组织自由基代谢影响[J].中国公共卫生,2014,30(9):1165-1167.
[16] 韦素珍,黄艳莲,陆贻逊,等.黄精提取液对老龄小鼠心、脑SOD和MDA含量的影响[J].中国医药导报,2010, 7(9):31-32.
[17] 杨华杰,龚千锋,于欢.黄精不同炮制品抗疲劳及抗氧化作用比较研究[J].江西中医药,2018,49(2):64-67.
[18] 赵小贞,王玮,康仲涵,等.血管性痴呆大鼠海马超微结构的变化及药物干预[J].解剖学杂志,2005,28(3):311-315.
[19] Yang JX,Wu S,Huang XL,et al. Hypolipidemic Activity and Antiatherosclerotic Effect of Polysaccharide of Polygonatum sibiricum in Rabbit Model and Related Cellular Mechanisms [J]. Evid Based Complement Alternat Med,2015,2015:391065.
[20] Xing C,Hayakawa K,Lok J,et al. Injury and repair in the neurovascular unit [J]. Neurol Res,2012,34(4):325-330.
[21] Wang YJ,Chen KY,Kuo LN,et al. The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury [J]. BMC Med Genet,2018,19(1):13.
[22] 祝凌丽,徐维平,魏伟,等.黄精总皂苷对慢性应激模型大鼠的行为学以及对海马的BDNF和TrkB表达的影响[J].中国新药杂志,2010,19(6):518-525.
[23] Dietrich HH. Cell-to-cell communication and vascular dementia [J]. Microcirculation,2012,19(5):461-467.
[24] 唐伟,王威,谭丽阳,等.黄精多糖对慢性脑缺血大鼠学习记忆能力及脑组织超微结构影响[J].中国中医药科技,2017,24(2):173-176.
[25] 王威,刘文博,唐伟,等.黄精多糖对慢性脑缺血大鼠学习记忆及脑组织β-淀粉样蛋白表达的影响[J].中医药导报,2016,22(16):26-29.
[26] 韩立秀,王兰琴,董瑞国.亚低温对大鼠全脑缺血再灌注后海马CA1区星形胶质细胞胶质纤维酸性蛋白表达及超微结构改变的影响[J].中华物理医学与康复杂志,2010,32(11):826-830.
[27] 赵小贞,王玮,康仲涵.黄精口服液对血管性痴呆大鼠行为和海马星形胶质细胞的影响[J].中华行为医学与脑科学杂志,2008,17(10):875-877.
[28] 未小明,王爱梅,罗朝辉,等.黄精对AD模型大鼠空间学习记忆及α7nAChR表达的影响[J].神经解剖学杂志,2016,32(3):391-396.
[29] 李明.黄精多糖对运动疲劳大鼠抗氧化及神经递质的影响[J].食品科技,2014,39(9):227-230.
[30] 田允,宋文婷,徐立,等.在体观测补肾中药对帕金森病模型小鼠纹状体多巴胺含量的影响[J].福建中医药大学学报,2011,21(1):17-20. |
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