不同五味子类木脂素成分对损伤肝细胞的保护作用比较

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Abstract Objective To evaluate the protective effects of deoxyschizandrin, schisandrin B, schisandrol A, schisandrol B, schisandrin C and schisantherin A on injured hepatocytes, respectively. Methods The H2O2 was used to induce model of injured HL-7702. In the deoxyschizandrin groups, the cells were randomly divided into normal group, model group and 1, 5, 25 μmol/L of deoxyschizandrin dosing group. The influence of deoxyschizandrin for the proliferation (A value) of injured HL-7702 was detected by cell counting kit-8, meanwhile, the influence of deoxyschizandrin for the aspartate aminotransferase (AST) released by the injured hepatocytes was detected by automatic biochemistry analyzer. The other groups of schisandrin B, schisandrol A, schisandrol B, schisandrin C and schisantherin A had the same operation with deoxyschizandrin. Results Compared with model groups, there were no significant differences of A values and AST concentration in the three concentration groups of deoxyschizandrin and schisandrol A (P ＞ 0.05), while the A values in 1, 5 μmol/L groups of schisandrol B, schisandrin B, schisandrin C and 25 μmol/L group of schisantherin A were increased significantly (P ＜ 0.05), the AST concentrations in which were decreased significantly (P ＜ 0.05). Conclusion Deoxyschizandrin and schisandrol A without any methylenedioxy have no protective effects for the injured hepatocytes, while schisandrol B, schisandrin B, schisandrin C and schisantherin A with the methylenedioxy have certain protective effects for the injured hepatocytes.

Key words： Fructus Schisandrae Chinensis Dibenzocyclooctadiene lignans Methylenedioxy Active group Oxidative damage Hepatoprotective effect

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	WANG Chenping1 XU Bo2 CAI Xiangming3 DOU Zhihua1

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WANG Chenping1 XU Bo2 CAI Xiangming3 DOU Zhihua1. Comparison on the protective effects of dibenzocyclooctadiene lignans contents of Fructus Schisandrae Chinensis for the injured hepatocytes[J]. 中国医药导报, 2017, 14(19): 35-38.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I19/35

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