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| Estimated value of serum cystatin C for the risk stratification of non ST-elevation acute coronary syndrome patients with normal renal function |
| CHEN Chao XU Tongda |
| Department of Cardiology, Affiliated Hospital of Xuzhou Medical University, Jiangsu Province, Xuzhou 221002, China |
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Abstract Objective To explore the estimated value of serum cystatin C (CysC) for the risk stratification of non ST-elevation acute coronary syndrome (NSTE-ACS) patients with normal renal function. Methods Two hundred and eighty patients diagnosed as NSTE-ACS by coronary angiography in Affiliated Hospital of Xuzhou Medical University from January 2015 to December 2016 were selected as experimental group, 40 healthy subjects without NSTE-ACS diagnosed by coronary angiography were selected as control group. According to the scores of global registry of acute coronary events (GRACE), the experimental group was further divided into low risk group (≤108 points, 47 cases), moderate risk group (109-140 points, 106 cases) and high risk group (＞140 points, 127 cases). The differences of CysC between different groups and the correlation with GRACE score were explored, the independent predictive factors of GRACE scores were investigated, the estimated value of CysC for high risk of NSTE-ACS was analyzed by receiver operating characteristics (ROC), the independent predictive factors of high risk of NSTE-ACS were analyzed by Logistic multivariate regression analysis. Results The levels of CysC in experimental group were significantly higher than those of control group (P ＜ 0.05). The levels of CysC were positively correlated with GRACE scores (r = 0.561, P ＜ 0.05). The CysC is an independent predictive factor of GRACE score and high risk of NSTE-ACS (P ＜ 0.05). The ROC curve analysis showed that AUC was 0.788, P ＜ 0.05, the best cut-off point was 0.94, the sensitivity was 77%, the specificity was 72%. Conclusion The levels of CysC in NSTE-ACS patients with normal renal function are closely related to its risk stratification, which is the independent predictive factor of risk stratification and high risk of NSTE-ACS.
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