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| Advances in research on the effects of salidroside on sepsis-induced myocardial dysfunction |
| ZHANG Haidan1 LI Peiwu2 MA Li3 |
1.Lanzhou University, Gansu Province, Lanzhou 730030, China;
2.Emergency Center, the Second Hospital of Lanzhou University, Gansu Province, Lanzhou 730030, China;
3.Intensive Care Unit 3, the Second Hospital of Lanzhou University, Gansu Province, Lanzhou 730030, China |
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Abstract Salidroside is one of the active constituents of Rhodiola and has a variety of pharmacological activities. Sepsis-induced myocardial dysfunction (SIMD) is an important cause of poor prognosis in sepsis. It is believed that the mechanism of SIMD is mainly related to the direct action of myocardial inhibitory factor, myocardial energy metabolism disorder, calcium ion transport disorder, myocardial apoptosis, renin-angiotensin-aldosterone system (RAAS) abnormalities, adrenergic signal inhibition and other factors. This article will combine the recent experimental research at home and abroad to try to explore the protective mechanism of salidroside on SIMD from the perspective of pathophysiology, and provide theoretical basis for further in-depth research and clinical application.
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[1] ShankarHari M，Phillips GS，Levy ML，et al. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock：For the Third International Consensus Definitions for Sepsis and Septic Shock（Sepsis-3）[J]. Jama，2016，315（8）：775-787.
[2] Deutschman C，Tracey K. Sepsis：Current Dogma and New Perspectives [J]. Immunity，2014，40（4）：463-475.
[3] Hawiger J，Veach RA，Zienkiewicz J. New paradigms in sepsis：from prevention to protection of failing microcirculation [J]. J Thromb Haemost，2015，13（10）：1743-1756.
[4] Sharawy N，Lehmann C. New directions for sepsis and septic shock research [J]. J Surg Res，2015，194（2）：520-527.
[5] Liu GE，Ouyang Q，Li L. Inflammationomics - A new concept to explore the new sepsis [J]. Chin J Traumatol，2015， 18（5）：251-253.
[6] Timmermans K，Kox M，Scheffer GJ，et al. DANGER IN THE INTENSIVE CARE UNIT：DAMPS IN CRITICALLY ILL PATIENTS [J]. Shock，2016，45（2）：108-116.
[7] Bronkhorst MW，Patka P，Van Lieshout EM. Effects of Sequence Variations in Innate Immune Response Genes on Infectious Outcome in Trauma Patients：A Comprehensive Review [J]. Shock，2015，44（5）：390-396.
[8] Suzuki T，Suzuki Y，Okuda J，et al. Sepsis-induced cardiac dysfunction and β-adrenergic blockade therapy for sepsis [J]. J Crit Care，2017，5（1）：22.
[9] 娄云鹏，林兆奋.脓毒症相关心肌功能障碍的发病机制[J].中华危重病急救医学，2018，30（4）：374-376.
[10] Vénéreau E，Ceriotti C，Bianchi ME. DAMPs from Cell Death to New Life [J]. Front Immunol，2015，6：422.
[11] Antonucci E，Fiaccadori E，Donadello K，et al. Myocardial depression in sepsis：from pathogenesis to clinical manifestations and treatment [J]. J Crit Care，2014，29（4）：500-511.
[12] Jingyan L，Yujuan G，Yiming Y，et al. Salidroside Attenuates LPS-Induced Acute Lung Injury in Rats [J]. Inflammation，2017，40（8）：1-12.
[13] Lan KC，Chao SC，Wu HY，et al. Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1 [J]. Sci Rep，2017，7（1）：12026.
[14] Tang Y，Vater C，Jacobi A，et al. Salidroside exerts angiogenic and cytoprotective effects on human bone marrow-derived endothelial progenitor cells via Akt/mTOR/p70S6K and MAPK signalling pathways [J]. Br J Pharmacol，2014，171（9）：2440-2456.
[15] Qi Z，Zhang Y，Qi S，et al. Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation of SirT1 during Inflammation [J]. Oxid Med Cell Longev，2017， 2017：9821543.
[16] Tomita K，Takashina M，Mizuno N，et al. Cardiac fibroblasts：contributory role in septic cardiac dysfunction [J]. J Surg Res，2015，193（2）：874-887.
[17] 李善华，黄萍，陈琴，等.红景天苷对博莱霉素诱导大鼠肺纤维化后VEGF及MMP表达的影响[J].实用药物与临床，2016，19（11）：1340-1343.
[18] 黄献欢，黄维，高兴华.红景天苷抑制大鼠肺纤维化机制研究[J].临床和实验医学杂志，2018，17（4）：343-345.
[19] 王文杰，陈红英，彭吉霞，等.红景天苷对大鼠心肌缺血预处理后血管内皮生长因子表达的影响[J].中国医药导报，2015，12（9）：29-33.
[20] 李茂林，王祝峰，章薇，等.红景天苷对大鼠颅脑损伤的保护作用研究[J].中华神经外科疾病研究杂志，2016， 15（2）：128-131.
[21] 刘萌萌，李彦文，周庆彪，等.氯气吸入致大鼠肺血管内皮细胞的线粒体损伤及红景天苷的干预作用[J].癌变·畸变·突变，2018，30（1）：31-36，41.
[22] 佟昌慈，柳云恩，金红旭，等.红景天苷对脂多糖诱导的急性肺损伤的保护机制研究[J].临床急诊杂志，2015， 16（9）：667-671.
[23] Wagner S，Schurmann S，Hein S，et al. Septic cardiomyopathy in rat LPS-induced endotoxemia：relative contribution of cellular diastolic Ca2+ removal pathways，myofibrillar biomechanics properties and action of the cardiotonic drug levosimendan [J]. Basic Res Cardiol，2015， 110（5）：507.
[24] 雷尚芳，郭俐宏，鲍升娟，等.红景天苷对大鼠急性心肌缺血/再灌注损伤离体心脏心功能的影响[J].实用药物与临床，2015，18（11）：1289-1292.
[25] 邓节喜，陈劲松，王子敬，等.红景天苷对心肺复苏后大鼠心脏功能的保护作用[J].中国急救医学，2013，33（2）：153-156.
[26] 李杰，李俊锋，魏婷婷，等.红景天苷对急性心肌缺血大鼠心肌细胞凋亡的作用及机制研究[J].临床与病理杂志，2016，36（7）：893-897.
[27] 刘善淘，朱锦灿，陈小宇，等.红景天苷对内皮祖细胞的辐射防护作用[J].中国病理生理杂志，2016，32（2）：240-244. |
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