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| Effect of interferon α-1b sequential Lamivudine combined therapy on T lymphocyte subsets, complement levels and liver function in children with chronic hepatitis B |
| LI Bo1 ZHENG Huanwei2▲ ZHAO Zhaoxia3 LI Jianxia4 XU Jianping5 JIN Peng6 |
1.Department of Pediatrics, Shijiazhuang Fifth Hospital, Hebei Province, Shijiazhuang 050024, China;
2.Department of Infectious Disease, Shijiazhuang Fifth Hospital, Hebei Province, Shijiazhuang 050024, China;
3.Department of Clinical Laboratory, Shijiazhuang Fifth Hospital, Hebei Province, Shijiazhuang 050024, China;
4.Department of Obstetrics and Gynecology, Pingshan County Hospital of Traditional Chinese Medicine, Hebei Province, Shijiazhuang 050400, China;
5.Department of Obstetrics and Gynecology, the Fifth Hospital of Shijiazhuang City, Hebei Province, Shijiazhuang 050024, China;
6.Department of Scientific Education, Shijiazhuang Fifth Hospital, Hebei Province, Shijiazhuang 050024, China |
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Abstract Objective To investigate the effects of interferon α-1b sequential Lamivudine on the expression of T lymphocyte subsets and complement in children with chronic hepatitis B, and to evaluate liver function. Methods A total of 136 children with chronic hepatitis B admitted to the Shijiazhuang Fifth Hospital (“our hospital” for short) from November 2015 to December 2017 were selected as subjects. They were divided into study groups according to the random number table method, and 68 cases in each group. The control group received only intramuscular injection of interferon α-1b. The study group was treated with Lamivudine combined interferon α-1b. The T lymphocyte subsets (CD4+, CD8+, CD4+/CD8+), CD8+ T cell PD-1, Tim-3 expression, complement (C3, C4) levels were observed before and after treatment in two groups. The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBil) were observed before and after treatment in both groups. Results After treatment, the levels of CD4+, CD4+/CD8+ in the study group were higher than those in the control group, and the levels of CD8+ in the study group were lower than those in the control group (P < 0.05). After treatment, the levels of CD8+ T cell PD-1, CD8+ Tim-3 in the study group were lower than those in the control group, while the levels of C3 and C4 in the study group were higher than those in the control group (P < 0.05). After treatment, ALT, AST and TBil in the two groups were lower than those before treatment, and the differences between the study group and the control group were statistically significant (P < 0.05). Conclusion Lamivudine combined with interferon α-1b in the treatment of children with chronic hepatitis B can significantly improve the T lymphocyte subsets of children, HBV DNA, HBsAg, HBeAg levels are significantly improved, with significant anti-fibrosis effect.
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