西替利嗪滴剂联合布地奈德混悬液对小儿哮喘急性发作FENO和SOD的影响

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Abstract Objective To investigate the effect of Cetirizine drops combined with Budesonide Suspension aerosol inhalation on acute attack of asthma in children and its effects on serum superoxide dismutase (SOD) and exhaled nitric oxide (FENO). Methods A total of 140 children with acute asthma exacerbations from July 2014 to February 2017 in Tangshan People′s Hospital of Hebei Province were enrolled and randomly divided into control group (n = 71) and observation group (n = 69). The control group received Budesonide Suspension inhalation therapy on the basis of symptomatic treatment, while the observation group received Cetirizine drops combined with Budesonide Suspension aerosol inhalation treatment on the basis of symptomatic treatment. The total effective rate, the first second forced expiratory volume (FEV1), the percentage of FEV1 in the predicted value (FEV1%), serum SOD activity and FENO content were compared between the two groups. Results The total effective rate of the control group was lower than that of the observation group (P < 0.05). There was no significant difference in FEV1, FEV1%, serum SOD activity and FENO content between the two groups before treatment (P > 0.05). After treatment, FEV1, FEV1% and serum SOD activity in the two groups were higher than those before treatment, while FENO content was lower than that before treatment, the differences were statistically significant (P < 0.05). After treatment, the FEV1, FEV1% and SOD activity in the control group were lower than those in the observation group, while the content of FENO in the control group was higher than that in the observation group, with statistical significance (P < 0.01). Conclusion Compared with Budesonide Suspension alone, Cetirizine drops combined with Budesonide Suspension can effectively alleviate acute attack of asthma in children, improve lung function, increase serum SOD activity and reduce FENO content.

Key words： Acute pediatric asthma attack Cetirizine Budesonide Superoxide dismutase Nitric oxide

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	WU Bingmei1 YANG Xuebing1 KOU Yongmei1 DONG Xiaona2

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WU Bingmei1 YANG Xuebing1 KOU Yongmei1 DONG Xiaona2. Effects of Cetirizine drops combined with Budesonide Suspension on FENO and SOD in children with acute asthma[J]. 中国医药导报, 2019, 16(14): 144-146.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I14/144

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