银杏达莫联合醒脑静对外伤性脑出血患者疗效及神经功能恢复的影响

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Abstract Objective To explore the efficacy of Ginkgo dipyridamole combined with Xingnaojing in patients with traumatic intracranial hemorrhage and its effect on neurological function recovery. Methods Eighty patients with traumatic cerebral hemorrhage admitted to the Cangzhou Hospital of integrated TCM-WM·Hebei from January 2017 to May 2018 were divided into control group (n = 40) and study group (n = 40) according to the random number table method. The patients in the control group were treated with Xingnaojing, and the patients in the study group were treated with Ginkgo dipyridamole on the basis of the control group. Both groups were treated for 14 days. The clinical effects of the two groups were compared. The levels of nerve growth factor (NGF), human brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY), National Institute of Health Stroke Scale (NIHSS) and Glasgow Coma Scale (GCS) scores were compared before and after treatment. At the same time, the adverse reactions of the two groups were observed during the treatment. Results The total effective rate of the study group was significantly higher than that of the control group (P < 0.05). The levels of NGF, BDNF and GCS score in the two groups were higher than those in the control group before treatment, and the study group was higher than the control group (P < 0.05 or P < 0.01). The NPY level and NIHSS scores of the two groups were lower than those before treatment, and the study group was lower than the control group (P < 0.05 or P < 0.01). There were no serious adverse reactions during the treatment period in both groups. Conclusion Ginkgo dipyridamole combined with Xingnaojing has definite curative effect on traumatic cerebral hemorrhage. It can significantly improve the neurological function of patients with good safety and has certain clinical application value.

Key words： Ginkgo dipyridamole Xingnaojing Traumatic intracranial hemorrhage Efficacy Neurological function

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	TIAN Wenyan1 TIAN Shousen2▲ LU Qiang3 LIU Zhen2 LIU Qianqian2 PAN Liang4

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TIAN Wenyan1 TIAN Shousen2▲ LU Qiang3 LIU Zhen2 LIU Qianqian2 PAN Liang4. Effect of Ginkgo dipyridamole combined with Xingnaojing in patients with traumatic intracranial hemorrhage and its effect on neurological function recovery[J]. 中国医药导报, 2019, 16(14): 140-143.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I14/140

[1] Hsu PJ，Lee CW，Tang SC，et al. Pearls & Oy-sters：Delayed traumatic intracerebral hemorrhage caused by cerebral venous sinus thrombosis [J]. Neurology，2014，83（14）：e135-e137.
[2] Nie Q，Guo P，Ge J，et al. Cerebral venous sinus thrombosis with cerebral hemorrhage during early pregnancy [J]. Neurosciences （Riyadh），2015，20（1）：48-51.
[3] 火雷鸣.醒脑静对脑出血患者脑损害的保护作用[J].中国老年学杂志，2015，35（2）：514-515.
[4] 陈爱男，张志明，祝兆林，等.醒脑静联合纳洛酮对脑出血意识障碍患者的促醒作用[J].中国中西医结合急救杂志，2016，23（6）：649-650.
[5] Liu S，Wu JR，Zhang D，et al. Comparative efficacy of Chinese herbal injections for treating acute cerebral infarction：a network meta-analysis of randomized controlled trials [J]. BMC Complement Altern Med，2018，18（1）：120.
[6] 张均，王强.银杏达莫联合依达拉奉治疗急性脑梗死72例疗效分析[J].北华大学学报：自然科学版，2016，17（2）：225-228.
[7] 曾振宇，易启兰，陈建辉，等.银杏达莫治疗冠心病不稳定性心绞痛的疗效及其对内皮细胞功能的影响[J].西部医学，2016，28（3）：361-364.
[8] 全国第四届脑血管病学学术会议组.各类脑血管疾病诊断要点及临床功能缺损程度评分标准（1995）[J].中华神经科杂志，1996，29（6）：379-383.
[9] 姜扬，李晓秋，隋轶，等.急性缺血性脑卒中患者血清PTX3水平变化及其与神经功能缺损和近期预后的关系[J].山东医药，2017，57（27）：52-54.
[10] 马骏，陈锷峰，屠传建，等.急性高血压脑出血患者脑糖氧代谢变化及意义[J].中华急诊医学杂志，2014，23（3）：314-319.
[11] 郭作隆，邹兴军.甘露醇应用时机对中等量脑出血患者疗效及相关指标的影响[J].中国药房，2016，27（21）：2926-2928.
[12] Richard SA，Ye Y，Li H，et al. Glioblastoma multiforme subterfuge as acute cerebral hemorrhage：A case report and literature review [J]. Neurol Int，2018，10（1）：7558.
[13] Feng X，Zhao T，Liu J，et al. Cerebral Venous Sinus Thrombosis with Cerebral Hemorrhage Presenting with Status Epilepticus in Early Pregnancy [J]. Clin Lab，2018，64（4）：611-614.
[14] 梅春龙，徐艳.加味大承气汤灌肠结合无创通气治疗急性非外伤性脑出血并发呼吸衰竭疗效观察[J].现代中西医结合杂志，2017，26（24）：2707-2709.
[15] 张青，蒋艳霞，李国良，等.醒脑静合生脉注射液对大鼠脑出血后凝血酶受体-1表达的影响[J].解剖学报，2013，44（5）：630-634.
[16] 黄正主.醒脑静联合盐酸纳洛酮治疗脑出血后昏迷患者的临床效果分析[J].贵阳中医学院学报，2013，35（2）：61-63.
[17] 王希佳，李星，周子英，等.银杏达莫联合醒脑静治疗脑出血患者疗效及对外周血S100 B、神经肽Y水平的影响[J].世界中医药，2017，12（12）：2916-2918.
[18] 王盛，王朝平，陈太董，等.神经节苷脂联合银杏达莫对颅脑损伤患者的临床研究[J].中国临床药理学杂志，2016， 32（12）：1075-1077.
[19] 张扬，张晓娜，韩志国，等.银杏达莫对大鼠蛛网膜下腔出血后症状性脑血管痉挛的影响[J].中国老年学杂志，2012，32（21）：4714-4716.
[20] 林小艳，白金娥.银杏达莫联合高压氧治疗高血压脑出血术后的疗效观察[J].安徽医药，2018，22（1）：156-159.