妊娠期糖尿病孕产妇所生新生儿血糖与糖化血清白蛋白、胰岛素及C肽的关系

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Abstract Objective To investigate the relationship among blood glucose and glycated albumin, insulin and C-peptide in neonates born by gestational diabetes (GMD) women. Methods From February 2017 to April 2018, in Baoding First Central Hospital, 293 neonates born were selected, according to the neonatal blood glucose and whether the neonatal mother had GDM or not, the neonates were divided into GDM mothers′ neonates hypoglycemia group (74 cases), GDM mothers' normal blood glucose group (68 cases), non-GDM mothers′ neonatal hypoglycemia group (16 cases), non-GDM mothers' normal blood glucose group (135 cases). Glycated albumin, C-peptide, fasting insulin level (FINS), insulin sensitivity index (ISI) and insulin resistance index (HOMA-IR) in groups were detected and compared, and the correlation between the above indicators and neonatal blood glucose was analyzed. Results The incidence of neonatal hypoglycemia in neonates born by GDM mothers was higher than that in neonates born by non-GDM mothers (P < 0.05). The levels of FINS, ISI, HOMA-IR and C-peptide in GDM mothers′ neonates hypoglycemia group were higher than those in GDM mothers' normal blood glucose group, the differences were statistically significant (P < 0.05). There was no significant difference in glycated albumin, FINS, ISI, HOMA-IR and C-peptide in non-GDM mothers′ neonatal hypoglycemia group and non-GDM mothers′ normal blood glucose group (P > 0.05). Further analysis showed that the above indicator were negatively correlated with FINS, ISI, HOMA-IR and C-peptide in neonates born by GDM mothers (r = -0.581, -0.712, -0.642, -0.621, P < 0.05). There was no significant correlation between glycosylated serum albumin and blood glucose (P > 0.05). Conclusion Neonates born by GDM mothers are prone to hypoglycemia, and the correlation between neonatal blood glucose and insulin and C-peptide level is significantly negative, with neonatal glycated albumin alone can not estimate whether hypoglycemia occurs in neonates after birth.

Key words： Gestational diabetes Neonate Hypoglycemia Glycated albumin Insulin sensitivity

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	WANG Kun WANG Pengchun YANG Mei

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WANG Kun WANG Pengchun YANG Mei. Relationship between neonatal blood glucose and glycated albumin, insulin and C-peptide in neonates born by gestational diabetes women[J]. 中国医药导报, 2019, 16(14): 132-135.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I14/132

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