|
|
|
| Relationship between serum FGF23 and FA level and coronary artery calcification in patients with maintenance hemodialysis |
| DUAN Chaoyang1 LIN Yan2 GAO Jie1 HAN Jin1 MA Xiaotao1 LU Jiamei1 LYU Zhian1 WANG Li1 |
1.Department of Nephrology, Second Affiliated Hospital of Xi′an Jiaotong University, Shaanxi Province, Xi′an 710004, China;
2.Endocrine Diabetes Hospital of Shaanxi People′s Hospital, Shaanxi Province, Xi′an 710068, China |
|
|
|
Abstract Objective To investigate the relationship between serum fibroblast growth factor 23 (FGF23) and fetoprotein A (FA) levels and coronary artery calcification in patients with maintenance hemodialysis. Methods From April 2016 to April 2017, 97 cases of maintenance hemodialysis patients admitted to the Second Affiliated Hospital of Xi′an Jiaotong University were selected. All patients underwent MSCT, and according to coronary artery Agaston score (CACs), the patients were divided into non-calcification group (CACs＜10 points) 21 cases, mild calcification group (11 points≤CACs＜100 points) 33 cases, moderate calcification group (100 points≤CACs＜400 points) 24 cases, and severe calcification group (CACs＞400 points) 19 cases. Basic data and biochemical indexes of the patients in each group were compared, and correlation analysis was conducted. Results The age of patients in the severe calcification group was significantly higher than that in the non-calcification group, the mild calcification group and the moderate calcification group, and the duration of dialysis was longer than that in the non-calcification group, the mild calcification group and the moderate calcification group, and the duration of dialysis in the moderate calcification group was longer than that in the non-calcification group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in the prevalence of diabetes, hypertension and gender composition among the groups (P ＞ 0.05). The levels of serum phosphorus and FGF23 in the non-calcification group, mild calcification group, moderate calcification group and severe calcification group presented a gradually increasing trend, while the level of serum FA presented a gradually decreasing trend, the differences between the groups were statistically significant (all P ＜ 0.05). Blood urea nitrogen, serum creatinine, glomerular filtration rate, fasting blood glucose, total cholesterol, triglyceride, and serum calcium were compared between groups, and the differences were not statistically significant (P ＞ 0.05). Pearson correlation analysis showed that the degree of coronary artery calcification in patients with maintenance hemodialysis was positively correlated with age, duration of hemodialysis, serum phosphorus and serum FGF23 level, while negatively correlated with serum FA level (all P ＜ 0.05). Conclusion Serum FGF23 and FA levels are closely related to coronary artery calcification in patients with maintenance hemodialysis, and with the increase of serum FGF23 level and the decrease of FA level, the degree of coronary artery calcification in patients with maintenance hemodialysis becomes more serious.
|
|
|
|
|
|
[1] 李菊，李建兰，高爱民.中国终末期肾病患者行维持性血液透析的流行病学现况[J].实用临床医药杂志，2018，22（21）：160-162.
[2] 李辉.血液透析联合血液灌流对维持性血液透析患者钙磷代谢紊乱的影响[J].中西医结合心血管病电子杂志，2018，6（8）：56-57.
[3] 张艳，杨丽丽，王宇飞，等.维持性血液透析患者冠状动脉钙化与铁蛋白及相关因素分析[J].中国实用医刊，2017， 44（6）：29-32.
[4] Fukao W，Hasuike Y，Yamakawa T，et al. Oral Versus Intravenous Iron Supplementation for the Treatment of Iron Deficiency Anemia in Patients on Maintenance Hemodialysis-Effect on Fibroblast Growth Factor-23 Metabolism [J]. J Ren Nutr，2018，28（4）：270-277.
[5] Drew DA，Koo BB，Bhadelia R，et al. White matter damage in maintenance hemodialysis patients：a diffusion tensor imaging study [J]. BMC Nephrol，2017，18（1）：213.
[6] 张菲菲，高延霞，张雪晶，等.维持性血液透析患者胎球蛋白A和炎症水平与心脏瓣膜钙化的相关性[J].临床肾脏病杂志，2015，15（3）：142-146.
[7] 王喆，魏芳，陈海燕，等.冠状动脉钙化与维持性血液透析患者预后的关系[J].中华肾脏病杂志，2017，33（12）：900-905.
[8] Zhang C，Wang S，Zhao S，et al. Effect of lanthanum carbonate on coronary artery calcification and bone mineral density in maintenance hemodialysis patients with diabetes complicated with adynamic bone disease：A prospective pilot study [J]. Medicine （Baltimore），2017，96（45）：e8664.
[9] 陶睿，于书香.麻黄附子细辛汤合五苓散加味结合西医常规疗法治疗3期慢性肾脏病临床研究[J].国际中医中药杂志，2016，38（1）：33-36.
[10] Zhang R，Liu K，Yang L，et al. Reduced white matter integrity and cognitive deficits in maintenance hemodialysis ESRD patients：a diffusion-tensor study [J]. Eur Radiol，2015，25（3）：661-668.
[11] 盛广睿，李建英.慢性肾脏病血管钙化研究进展[J].世界最新医学信息文摘，2018，18（88）：44-46.
[12] 祝旭颖，蔡宏，张伟明，等.维持性血液透析患者血清成纤维细胞生长因子23与腹主动脉钙化及预后的关系[J].中华肾脏病杂志，2017，33（9）：678-685.
[13] 郁丽霞，顾晓霞，陈文君，等.血清FGF23和klotho水平与血液透析患者血管钙化的关系[J].徐州医科大学学报，2017，37（12）：836-838.
[14] 刘冰，李桂花，张瑾文，等.维持性血液透析患者心脏瓣膜钙化与IL-6、hs-CRP及Fetuin-A的关系分析[J].国际泌尿系统杂志，2018，38（2）：251-255.
[15] 易扬，路建饶，吴好，等.慢性肾脏病患者冠状动脉钙化影响因素分析[J].第二军医大学学报，2018，39（6）：621-626.
[16] Iguchi A，Kazama JJ，Yamamoto S，et al. Administration of Ferric Citrate Hydrate Decreases Circulating FGF23 Levels Independently of Serum Phosphate Levels in Hemodialysis Patients with Iron Deficiency [J]. Nephron，2015，131（3）：161-166.
[17] Anees M，Batool S，Imtiaz M，et al. Socio-economic factors affecting quality of life of Hemodialysis patients and its effects on mortality [J]. Pak J Med Sci，2018，34（4）：811-816.
[18] 徐丰博，孙懿，王银娜，等.维持性血液透析患者冠状动脉钙化的相关因素分析[J].首都医科大学学报，2015， 33（4）：630-633.
[19] Fukao W，Hasuike Y，Yamakawa T，et al. Oral Versus Intravenous Iron Supplementation for the Treatment of Iron Deficiency Anemia in Patients on Maintenance Hemodialysis-Effect on Fibroblast Growth Factor-23 Metabolism [J]. J Ren Nutr，2018，28（4）：270-277.
[20] Lu W，Ren C，Han X，et al. The protective effect of different dialysis types on residual renal function in patients with maintenance hemodialysis：A systematic review and meta-analysis [J]. Medicine （Baltimore），2018， 97（37）：e12325.
[21] 肖帅，张骏浩，王妍琦，等.胎球蛋白A与血管钙化的相关性研究[J].实用老年医学，2018，32（3）：286-288， 292. |
|
|
|
