颅内出血新生儿血清TNF-■与IL-1■的临床价值研究

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Abstract Objective To investigate the clinical value of serum TNF-α and IL-1β in neonates with intracranial hemorrhage. Methods From January 2015 to January 2017, 98 neonates with intracranial hemorrhage in Tianmen First People′s Hospital were selected as the subjects (intracranial hemorrhage group), and 50 healthy newborns at the same time were selected as the control group. The levels TNF-α and IL-1β in plasma were detected by ELISA assay at 24 h, 3, 7 d after birth respectively. The patients were followed up for 1 year, and the prognosis was statistically analyzed. Results The levels of plasma TNF-α and IL-1β in intracranial hemorrhage group were significantly higher than those in control group (P < 0.05). At the same time, plasma TNF-α and IL-1β levels gradually decreased after birth (P < 0.05). There was a significant difference in plasma TNF-α and IL-1β in neonates with bleeding volume in 24 h (P < 0.05). The neonates with highest blood volume had the highest plasma TNF-α and IL-1β levels (P < 0.05). There was a positive correlation between the amount of bleeding and the levels of TNF-α and IL-1β in neonates with intracranial hemorrhage (r = 0.409, 0.376; P < 0.05). The plasma TNF-α and IL-1β levels in the cure group were significantly lower than those in the unhealed group (P < 0.05). Conclusion The expression of TNF-α and IL-1β in plasma of neonates with intracranial hemorrhage increased abnormally, and positively correlated with the amount of hematoma. The prognosis of neonates with intracranial hemorrhage is closely related to plasma TNF-α and IL-1β, plasma IL-1β and TNF-α are significantly increased in neonateswith poor prognosis.

Key words： Intracranial hemorrhage Newborn TNF-α IL-1β

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	XU Huirong1 LU Yuanyue2 LI Yinhua1 WANG Hongyong1 WEI Dengfei1 SU Huaping1

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XU Huirong1 LU Yuanyue2 LI Yinhua1 WANG Hongyong1 WEI Dengfei1 SU Huaping1. Study of clinical value of serum TNF-α and IL-1β in neonates with intracranial hemorrhage [J]. 中国医药导报, 2019, 16(14): 63-66.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I14/63

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