血脂康胶囊治疗血脂异常的Meta分析

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Abstract Objective To evaluate the clinical efficacy and safety of Xuezhikang Capsules in the treatment of patients with dyslipidemia. Methods The databases of PubMed, Science Citation Index-Expanded, China National Knowledge Infrastructure, Wanfang Databases, Chinese VIP Information were searched up to June 2018 for randomized controlled trials about Xuezhikang in the treatment of dyslipidemia. Revman 5.3 software was used to make Meta-analysis. The effects of Xuezhikang Capsules on the serum levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) were evaluated. Results A total of 25 trials containing 7875 participants were analyzed. Meta-analysis showed that compared with blank control group, Xuezhikang could lower serum levels of TC (WMD = -1.05, 95%CI: -1.40, -0.70, P ＜ 0.01) and LDL-C (WMD = -0.76, 95%CI: -0.94, -0.58, P ＜ 0.01) more effectively, and increase HDL-C (WMD = 0.17, 95%CI: 0.08, 0.27, P ＜ 0.01) more effectively. Compared with statins control group, Xuezhikang could increase HDL-C (WMD = 0.17, 95%CI: 0.04, 0.30, P ＜ 0.05) more effectively, and also decrease serum TC and LDL-C levels, while there were no significant differences (P ＞ 0.05). Compared with control group, Xuezhikang showed advantages in decreasing serious side effects or major adverse cardiovascular events (WMD = 0.55, 95%CI: 0.47, 0.64, P ＜ 0.01). Conclusion Xuezhikang can regulate dyslipidemia effectively and comprehensively, with low rates of adverse events.

Key words： Xuezhikang Dyslipidemia Low density lipoprotein-cholesterol High density lipoprotein-cholesterol

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	ZHENG Sidao1 YANG Cui2 ZHANG Chengying2

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ZHENG Sidao1 YANG Cui2 ZHANG Chengying2. Meta-analysis of Xuezhikang Capsules in the treatment of patients with dyslipidemia[J]. 中国医药导报, 2019, 16(14): 51-55,78.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I14/51

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