不同途径吸入布地奈德气雾剂治疗儿童过敏性鼻炎哮喘综合征的临床效果对比

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Abstract [Abstract] Objective To discuss the clinical curative effect of different ways of inhaled Budesonide Aerosol in the treatment of combined allergic rhinitis and asthma syndrome (CARAS) in children. Methods A total of 113 children with mild and moderate CARAS in Department of Pediatrics of Shenzhen People's Hospital form June 2011 to January 2015 were selected as the research objects, and according to random number table method they were divided into group A (39 cases) treated through the mouth inhaled budesonide aerosol, 200 μg/time, 2 times/d; group B (36 cases) treated through the nasally inhaled Budesonide Aerosol, 200 μg/time, 2 times/d; and group C (38 cases) treated through the mouth inhaled Budesonide Aerosol (100 μg/time, 2 times/d) and the nasally inhaled budesonide nasal spray 200 μg/time (each side nasal spray 100 μg each time, 1 time/d); each group were treated for 8 weeks. Correlation parameters of patients in the three groups before and after the treatment were recorded and compared. Results Compared with the group A, the clinical symptom score, pulmonary function, EOS absolute value, and serum total IgE levels of the group B were improved significantly (all P < 0.05), the total effective rate was significantly higher (χ2 = 5.943, P < 0.05); compared the group B with the group C, the difference was not obviously significant (P > 0.05), but the incidence of adverse reactions of group C was significantly higher than the group A and B, and the difference between group B and group C was statistically significant (χ2 = 11.402, P < 0.05). Conclusion The curative effect through the nasally inhaled Budesonide Aerosol, 200 μg/time, 2 times/d (400 μg/d) treated with mild and moderate CARAS is distinct, with less adverse reactions, simple operation, it is worthy of clinical popularization and application.

Key words： [Key words] Allergic rhinitis Asthma Combined allergic rhinitis and asthma syndrome Budesonide Aerosol

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	CHEN Qiaorong1 LIU Guojun2 LIU Shenghua1 ZHANG Liangjing1 WU Lizhou2

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CHEN Qiaorong1 LIU Guojun2 LIU Shenghua1 ZHANG Liangjing1 WU Lizhou2. Clinical effect comparison of different ways of inhaled Budesonide Aerosol in the treatment of children with combined allergic rhinitis and asthma syndrome[J]. 中国医药导报, 2016, 13(3): 110-113.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2016/V13/I3/110

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