川崎病抗血栓治疗药物相关基因多态性研究进展

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Abstract Kawasaki disease (KD) with coronary artery aneurysm causing thrombosis is a serious complication of KD and a serious heart disease in children and their adulthood. Antithrombotic drugs include Aspirin, Clopidogrel, Warfarin and Dipyridamole. The individualized differences in the clinical treatment of these drugs are closely related to heredity. At present, there is no definite conclusion on Aspirin-related gene research, while more studies on Clopidogrel and more definite and unified conclusion are CYP2C19 and Warfarin-related are CYP2C9 and VKORC1, and no Dipyridamole-related gene research has been found. Most of these findings come from adult studies, and the related gene polymorphisms have been divided into different levels of evidence, which provides a direction for the study of antithrombotic therapy in children.

Key words： Kawasaki disease Antithrombotic therapy Aspirin Clopidogrel Warfarin Dipyridamole Gene polymorphisms

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	BAO Han LI Xiaohui

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BAO Han LI Xiaohui. Advances in research on gene polymorphisms of antithrombotic drugs in Kawasaki disease[J]. 中国医药导报, 2019, 16(11): 34-37.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I11/34

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