高尿酸血症和痛风的高危因素分析

Abstract
Figure/Table
References (20)
Related Citation (15)

Download: PDF (603 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore and analyze the correlation between high risk factors of hyperuricemia and gout. Methods From April 2015 to April 2017, 90 cases of hyperuricemia patients and 90 cases of gout patients admitted to the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine were selected as the hyperuricemia group and the gout group respectively, Logistic multivariate regression model was used to analyze the correlation between the occurrence of gout and obesity, liver function, blood lipid and other factors. Results Compared with the high uric acid group, the gout group had a higher proportion of male patients, higher proportion of patients with total cholesterol ≥5.72 mmol/L and triglycerin (TG) ≥1.71 mmol/L, and higher proportion of patients with high density lipoprotein cholesterol ＜0.91 mmol/L. The proportion of patients with low-density lipoprotein cholesterol(LDL-C) ≥3.37 mmol/L, apolipoprotein B ≥1.20 g/L and alanine aminotransferase ≥50 U/L was higher, and the difference were statistically significant (P ＜ 0.05). There was no significant difference in BMI and apolipoprotein A levels between the two groups (P ＞ 0.05). The above factors were analyzed by Logistic multivariate regression, and it was found that male, TG ≥1.71 mmol/L, and LDL-C≥3.37 mmol/L could be considered as high risk factors for gout (OR = 2.05, 2.45, 3.12, respectively). Conclusion Men can be the main morbidity group of gout, and high TG and LDL-C can be the high risk factors of gout.

Key words： Hyperuricemia Gout Risk factors Correlation

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHU Gang1
	2 HUANG Chuanbing2▲ LIU Sidi1
	2 SHI Zhouzhen1
	2 WANG Guizhen2 WAN Lei2

Cite this article:

ZHU Gang1,2 HUANG Chuanbing2▲ LIU Sidi1,2 SHI Zhouzhen1, et al. Analysis of risk factors for hyperuricemia and gout[J]. 中国医药导报, 2019, 16(8): 128-130.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I8/128

[1] 宋燕郡，于维森.痛风及无症状高尿酸血症饮食指导的研究进展[J].现代医药卫生，2016，32（8）：1187-1190.
[2] Leiba A，Vinker S，Dinour D，et al. Uric acid levels within the normal range predict increased risk of hypertension：A cohort study [J]. J Am Soc Hypertens，2015，9（8）：600-609.
[3] 郑淑瑛，周建平，胡瑜，等.模块式护理计划对痛风患者疼痛及生活质量的影响[J].中华现代护理杂志，2014，20（17）：2077-2079.
[4] Qin L，Yang Z，Gu H，et al. Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals [J]. BMC Cardiovasc Disord，2014，9（20）：2235-2261.
[5] 武广晔，田亚琼，黄娅，等.脑梗死患者血尿酸与血脂及颈动脉斑块形成的关系[J].中国实验诊断学，2014，18（8）：1247-1248.
[6] 雍雪莲，叶勇.某高校大学新生入学健康体检血尿酸检测结果分析[J].中国学校卫生，2014，35（9）：1430-1431.
[7] Rodenbach KE，Schneider MF，Furth SL，et al. Hyperuricemia and progression of CKD in children and adolescents：The chronic kidney disease in children（CKiD）cohort study [J]. Am J Kidney Dis，2015，66（6）：984-992.
[8] 柳旭，刘琼玲，万崇华.痛风病人生命质量量表研究现状[J].护理研究，2016，30（7C）：2561-2562.
[9] Ciarla S，Struglia M，Giorgini P，et al. Serum uric acid levels and metabolic syndrome [J]. Arch Physiol Biochem，2014，120（3）：119-122.
[10] 赵冰，聂庆东，屈飞飞，等.青年无症状高尿酸血症和血脂相关性研究[J].中国实验诊断学，2016，20（9）：10-11.
[11] 王占成，阮长武，姬文慧，等.无症状高尿酸血症与高血压关系的临床研究[J].医学综述，2013，19（23）：4367-4368.
[12] Kottgen A，Albrecht E，Teumer A，et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations [J]. Nat Genet，2013，45（2）：145-154.
[13] 杨丽辉，宋嘉，石荔，等.拉萨市区成年人高尿酸血症和痛风的流行病学调查[J].西部医学，2015，27（10）：1467-1468.
[14] Dalbeth N，House ME，Gamble GD，et al. Population-specific influence of SLC2A9 genotype on the acute hyperuricaemic response to a fructose load [J]. Ann Rheum Dis，2013，72（11）：1868-1873.
[15] 宋薇.高尿酸血症和痛风的流行病学及影响因素研究进展[J].江西医药，2013，48（5）：123-124.
[16] Li Z，Ding H，Chen C，et al. Novel URAT1 mutations caused acute renal failure after exercise in two Chinese families with renal hypouricemia [J]. Gene，2013，512（1）：97-101.
[17] Zhou D，Liu Y，Zhang X，et al. Functional polymorphisms of the ABCG2 gene are associated with gout disease in the Chinese Han male population [J]. Int J Mol Sci，2014， 15（5）：9149-9159.
[18] 关宝生，白雪，王艳秋，等.痛风/高尿酸血症患者生活习惯的危险因素[J].中国老年学，2014，34（2）：455-456.
[19] Xiong A，Yao Q，He J，et al. No causal effect of serum urate on bone-related outcomes among a population of postmenopausal women and elderly men of Chinese Han ethnicity-a mendelian randomization study [J]. Osteoporos Int，2016，27（3）：1031-1039.
[20] 孙莹，陆萍静，牛海，等.西藏地区诱发高尿酸血症和痛风的危险因素研究[J].护理研究，2018，32（4）：10-11.