|
|
|
| Serum adipocyte-type fatty acid binding protein and interleukin-17 levels in patients with type 2 diabetes mellitus and their relationship with lower limb atherosclerosis |
| WANG Lu1 BAI Hua1 HAN Mei1 ZHAO Yuyan2 |
1.Department of Endocrinology, Jinqiu Hospital of Liaoning, Liaoning Province, Shenyang 110016, China;
2.Department of Endocrinology, the First Affiliated Hospital, Chinese Medical University of Liaoning, Liaoning Province, Shenyang 110001, China |
|
|
|
Abstract Objective To investigate the relationship between serum adipocyte-type fatty acid binding protein (A-FABP) and interleukin-17 (IL-17) expression levels and lower limb atherosclerosis (LEAD) in patients with type 2 diabetes. Methods A total of 131 patients with type 2 diabetes admitted to Jinqiu Hospital of Liaoning Province (hereinafter referred to as "our hospital") from February 2017 to November 2017 were divided into non-lead group (n = 34) and non-lead group (n = 97) according to ankle-brakle index (ABI), and 45 healthy subjects in our hospital were randomly selected as the control group during the same period. Serum levels of A-FABP and IL-17 were determined by enzyme-linked immunosorbent assay, and the influencing factors of LEAD in type 2 diabetes were analyzed by Logistic regression. ROC curve was used to evaluate the predictive value of A-FABP and IL-17 on LEAD. Results The duration of diabetes in the LEAD group was longer than that in the non-lead group (P ＜ 0.05). The systolic blood pressure, glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), low-density lipoprotein cholesterol (LDL-C), serum creatinine (SCr), A-FABP, and IL-17 levels in the LEAD group and the non-lead group were higher than those in the control group (P ＜ 0.05). Multivariate Logistic regression analysis showed that LDL-C, A-FABP and IL-17 were independent risk factors of LEAD in type 2 diabetes (OR = 1.418, 1.657, 1.619, P ＜ 0.05). The area under the curve (AUC) of A-FABP combined with IL-17 was 0.906, the sensitivity and specificity were 0.89 and 0.86, respectively, and the accuracy was 0.90. Conclusion Serum A-FABP and IL-17 are independent risk factors of LEAD in patients with type 2 diabetes. Early combined detection is helpful to predict LEAD in the early clinical stage, so as to guide clinical development of early intervention measures.
|
|
|
|
|
|
[1] 黄斌，麦世龙，刘伯奇.FPG，HbA1c，GA及OGTT-2hPG联合检测对肇庆市城区2型糖尿病患者疗效监测的探讨[J].国际检验医学杂志，2018（22）：2801-2803，2808.
[2] 韦荣文，韦景秋，王惠香.彩色多普勒超声对2型糖尿病患者下肢动脉粥样硬化血管病变的诊断价值[J].中国当代医药，2014，21（8）：127-129.
[3] 中华医学会糖尿病学分会.中国2型糖尿病防治指南（2013年版）[J].中华糖尿病杂志，2014，6（7）：447-498.
[4] Signorelli SS，Katsiki N. Oxidative stress and inflammation：their role in the pathogenesis of peripheral artery disease with or without type 2 diabetes mellitus [J]. Curr Vasc Pharmacol，2018，16（6）：547-554.
[5] 刘玮，郑亚虹，沈颖，等.血清脂肪细胞型脂肪酸结合蛋白和白细胞介素-17水平与2型糖尿病患者下肢动脉粥样硬化病变的相关性研究[J].安徽医科大学学报，2018， 53（7）：1085-1088.
[6] Lin YP，Xu CL，Lin KS，et al. Study on the correlation between adipocyte fatty-acid binding protein，glucolipid me-tabolism，and pre-eclampsia [J]. J Obstet Gynaecol Res，2018，44（4）：655-662.
[7] Qu N，Xu M，Mizoguchi I，et al. Pivotal roles of T-helper 17-related cytokines，IL-17，IL-22，and IL-23，in inflammatory diseases [J]. Clin Dev Immunol，2013，2013：968549.
[8] 陆再英，终南山.内科学[M].北京：人民卫生出版社，2008：778.
[9] 叶庆邦，蔡茵瑜，卓华钦.2型糖尿病肾病下肢动脉粥样硬化患者超氧化物歧化酶（SOD）水平及其影响因素分析[J].吉林医学，2018，39（9）：1635-1636.
[10] 周璠娅.彩色多普勒超声在2型糖尿病下肢动脉粥样硬化血管病变中的诊断价值[J].现代中西医结合杂志，2015，24（18）：2027-2029.
[11] 朱静和，徐昌辉，钱雷，等.IL-35在2型糖尿病合并颈动脉粥样硬化病变中的作用[J].江苏大学学报：医学版，2018，28（5）：431-436.
[12] 马少燕.彩色多普勒超声对糖尿病患者下肢动脉病变检测的回顾性分析[J].山西医药杂志，2012，41（2）：145-146.
[13] 何雪环，黄光联，何英爱，等.脂联素联合FGF-21、A-FABP在2型糖尿病的早期诊断中的应用价值分析[J].心电图杂志：电子版，2018，7（1）：39-40.
[14] 李敏，古丽娜孜·吐尔逊，段伯焕.2型糖尿病合并非酒精性脂肪性肝病患者A-FABP水平与胰岛素抵抗的相关性研究[J].临床和实验医学杂志，2017，16（15）：1487-1490.
[15] Wu G，Li H，Zhou M，et al. Mechanism and clinical evidence of lipocalin-2 and adipocyte fatty acid-binding protein linking obesity and atherosclerosis [J]. Diabetes Metab Res Rev，2014，30（6）：447-456.
[16] 王庆丽，卢颖，赵慧颖.冠心病患者血清visfatin，A-FABP，IL-6水平与冠状动脉粥样硬化的相关性研究[J].中国循证心血管医学杂志，2016，8（7）：865-867，874.
[17] 朱婕，曹永涛，车红梅，等.血清IL-17、PCT和hs-CRP水平在早期判断冠状动脉侧支循环形成中的临床意义[J].中西医结合心脑血管病杂志，2018，16（19）：2854-2856.
[18] Autieri MV. Adipose inflammation at the heart of vascular disease [J]. Clin Sci（Lond），2016，130（22）：2101-2104.
[19] Erbel C，Akhavanpoor M，Okuyucu D，et al. IL-17A influences essential functions of the monocyte/macrophage lineage and is involved in advanced murine and human atherosclerosis [J]. J Immunol，2014，193（9）：4344-4355.
[20] 周晓蓉.彩色多普勒超声对糖尿病患者下肢血管早期病变的诊断价值[J].实用医技杂志，2011，18（2）：154-155.
[21] 钟姣.2型糖尿病患者HbA1c、血脂水平与颈动脉内膜中层厚度的相关性研究[J].中外医学研究，2017，15（30）：10-11.
[22] 崔丽梅，吕纳强，刘翠平，等.初诊2型糖尿病患者血清维生素D与大血管病变的关系[J].中国医药导报，2017， 14（3）：84-87. |
|
|
|
