高频振荡通气与西地那非联合治疗新生儿持续性肺动脉高压的临床效果

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Abstract Objective To investigate the effect of high frequency oscillatory ventilation combined with Sildenafil in the treatment of neonatal persistent pulmonary hypertension (PPHN). Methods A total of 109 newborns with PPHN admitted to the Affiliated Hospital of Chengde Medical College from March 2014 to March 2018 were selected as subjects. Newborns were divided into control group (54 cases) and study group (55 cases) according to random number table method. The control group was treated with high frequency oscillatory ventilation, and the study group was treated with Sildenafil. The clinical effect of the two groups was compared after 72 hours′ treatment. The arterial partial pressure of carbon dioxide (PaCO2), fraction of inspired oxygen (FiO2), arterial oxygen saturation (SaO2), arterial partial pressure of oxygen (PaO2), pulmonary artery pressure (SPAP) and systemic blood pressure (SBP) were compared between the two groups before and after treatment. Adverse reactions of the two groups during treatment were observed. Results The total effective rate of the study group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The PaCO2 and FiO2 of the two groups were lower than those before treatment, and those in the study group were lower than those in the control group (P ＜ 0.05). The SaO2 and PaO2 of the two groups increased after treatment, and those in the study group were higher than those in the control group (P ＜ 0.05). The SPAP of the study group after treatment was significantly lower than that before treatment (P ＜ 0.05), while there was no significant difference in the control group before and after treatment (P ＞ 0.05), and that in the study group was lower than the control group (P ＜ 0.05). There was no significant difference in SBP before and after treatment in the same group nor between the two groups (P ＞ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P ＞ 0.05). Conclusion High frequency oscillatory ventilation combined with Sildenafil in the treatment of PPHN is effective remarkbly, which can significantly improve clinical symptom and related clinical indicators, and it has high clinical application value.

Key words： High frequency oscillatory ventilation Sildenafil Neonatal persistent pulmonary hypertension Clinical study

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	WU Yanqiu1 XU Dongmei1 ZHOU Qili1 WANG Zhijie1 LIU Huiling2 DONG Zhiyong3 LIU Xia1

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WU Yanqiu1 XU Dongmei1 ZHOU Qili1 WANG Zhijie1 LIU Huiling2 DONG Zhiyong3 LIU Xia1. Clinical effect of high frequency oscillatory ventilation combined with Sildenafil in the treatment of neonatal persistent pulmonary hypertension[J]. 中国医药导报, 2019, 16(8): 88-91.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I8/88

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