慢性粒细胞白血病干细胞的微环境及对药物治疗反应的研究进展

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Abstract Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease. With the use of chemotherapy drugs such as tyrosine kinase, improve its clinical remission rate, but drug resistance is up to 15 percent and rising every year. It was found that residual leukemia stem cells (LSCs) in bone marrow microenvironment (BM) play an important role in the acquisition of drug resistance in patients with chronic myelogenous leukemia. LSCs secrete certain cytokines, which play a role in remodeling BM and establishing protective “niches”. Among them, the cytokine CCL3 in the microenvironment can recruit Nestin+ mesenchymal stem cells (MSCs) to form a protective “niche” to shelter LSCs; then TGF-β1 converts MSCs Nestin+ to -SMA +MSCs, becoming a mature “niche” protecting LSCs. Thereby tolerating the killing of chemotherapy drugs, leading to disease recurrence. On the other hand, the bone marrow microenvironment can cause abnormalities in the signaling pathways of LSCs, epigenetic changes, and increased activity of transmembrane transport proteins through a variety of mechanisms, resulting in the “monitoring” of LSCs to escape the immune system. This article reviews the BM and LSCs mediated chronic myelogenous leukemia drug resistance.

Key words： Chronic myeloid leukaemia Leukaemia stem cells Bone marrow microenvironment Drug resistance

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	HE Ling1
	2 ZHANG Xiaoyan3 YANG Yazhi2 LI Jian2▲

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HE Ling1,2 ZHANG Xiaoyan3 YANG Yazhi2 LI Jian2▲. Advances in microenvironment of chronic myelogenous leukemia stem cells and their response to drug therapy[J]. 中国医药导报, 2019, 16(8): 35-38.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I8/35

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