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| The effect of venous thrombolysis treatment of acute ischemic stroke with Ginkgo Injection combined with Alteplase |
| YU Libo1 WANG Shuai1 JIANG Ying2 GU Jiumei2 |
1.The Imaging Center, Chinese People′s Liberation Army 211 Hospital, Heilongjiang Province, Harbin 150000, China;
2.The Second Division of Neurology Department, Chinese People′s Liberation Army 211 Hospital, Heilongjiang Province, Harbin 150000, China |
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Abstract Objective To explore effect of venous thrombolysis treatment of acute ischemic stroke with Ginkgo Injection combined with Alteplase. Methods A total of 106 cases′ clinical data of acute ischemic stroke in the Second Division of Neurology Department, Chinese People′s Liberation Army 211 Hospital from May 2015 to July 2017 were selected and analyzed. All the cases were divided by different treatment method, with 53 cases in the control group (Alteplase therapy) and 53 cases in the observation group (Ginkgo Injection combined with Alteplase therapy). The two groups were treated for 14 days. The National Institute of Health Stroke Scale (NIHSS) scores, improve mRS score, fibrinogen (FIB), prothrombin time (PT), thrombin time (TT), life quality scores, activity of daily living Barthel index of the two groups were observed and the clinical efficacy, complications of the two groups were observed. Results Before treatment, the NIHSS scores, improve mRS scores, FIB, PT, TT, life quality scores and Barthel index of two groups were compared and there was no statistically significant differences (P ＞ 0.05). After treatment, the NIHSS scores, improve mRS scores in the two groups were lower than those in the two groups, life quality scores and Barthel index in the two groups were higher than those before treatment, the differences were significant (P ＜ 0.05). After treatment, the NIHSS scores, improve mRS scores in the observation group were lower than those in the control group while the life quality scores and Barthel index were higher than those in the control group, the differences were significant (P ＜ 0.05). After treatment, FIB was lower than that before treatment and PT, TT were higher than those before treatment in the control group (P ＜ 0.05). But there was no significant difference between FIB, PT, TT before and after treatment in the treatment group (P ＞ 0.05). After treatment, FIB in the observation group was higher than that in the control group and PT, TT were lower than those in the control group, all the differences were statistically significant (P ＜ 0.05). The total clinical treatment efficiency of the observation group was higher than that in the control group, and total complications rate were lower than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion The venous thrombolysis treatment of acute ischemic stroke with Ginkgo Injection combined with Alteplase could improve nerve function and life quality, by which the influence of blood coagulation dysfunction is little, the effect is remarkble, complications is few, and it is worth of promotion.
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