|
|
|
| Clinical effect of Valsartan combined with Captopril in treatment of elderly hypertensive patients |
| WEI Jingmei WANG Xiaozhou |
| Department of Hypertension, Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist Hospital, Qinghai Province, Xining 810000, China |
|
|
|
Abstract Objective To investigate the clinical effect of Valsartan combined with Captopril in elderly hypertensive patients. Methods From February 2016 to January 2017, in Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist Hospital, 174 elderly hypertensive patients were selected, according to according to draw lots of serial number, they were divided into two groups, with 87 cases in each group. The patients in control group were treated with Valsartan, the patients in study group were treated with Valsartan combined with Captopril. The blood pressure, heart rate changes, incidence of adverse reactions, NIHSS scores and clinical effects in two groups were compared. Results The blood pressure in two groups after treatment were better than before treatment, the differences were statistically significant (P < 0.05). The blood pressure and heart rate in study group were better than control group, the differences were statistically significant (P < 0.05). The NIHSS scores in two groups after 1 month were lower than before treatment, at 7 d after treatment, and the NIHSS scores in study group were lower than control group at 7 d, 14 d and 1 month after treatment, the differences were statistically significant (P < 0.05). Conclusion The treatment of valsartan combined with Captopril in elderly hypertensive patients is effective, it can not only reduce the incidence of adverse reactions in elderly hypertensive patients, but also improve the NIHSS score and clinical efficacy of patients, and it can also improve the blood pressure and heart rate of patients.
|
|
|
|
|
|
[1] 罗国荣，陈卫，陈箭.大剂量缬沙坦治疗老年高血压合并肾病患者的疗效及对肾功能相关指标、电解质的影响[J].中国老年学杂志，2016，36（10）：2381-2382.
[2] 程英，段菲.硝酸甘油联合卡托普利治疗心肌梗死临床疗效及其对纤维蛋白和C反应蛋白的影响[J].中国全科医学，2017，20（s1）：103-105.
[3] 徐双双，宋志霞，杨芦蓉，等.黄葵胶囊联合缬沙坦治疗糖尿病肾病的临床效果及对HIF-1α和VEGF水平的影响[J].中药材，2016，39（12）：2885-2888.
[4] 邵炀，曹佳宁.卡托普利联合厄贝沙坦片治疗老年高血压疗效观察[J].新乡医学院学报，2014，31（7）：566-568.
[5] 薛周山.降压药在老年高血压病患者中的临床药学特点分析[J].中国组织工程研究，2016，32（2）：115.
[6] 李秀芹，高勇.阿托伐他汀联合尤瑞克林对急性脑梗死患者临床疗效及内皮素水平的影响[J].中国老年学杂志，2016，36（9）：2146-2148.
[7] 左积文，韩岳，陈丽丽，等.神经生长因子联合奥拉西坦治疗高血压脑出血回顾性研究[J].中国医院药学杂志，2017，37（1）：65-68.
[8] 谢强，王飞，张慧.老年高血压脑出血患者应用复方麝香注射液配合血肿微创引流的效果及预后研究[J].中华中医药学刊，2016，12（9）：2228-2231.
[9] 刘曙艳，邓晓明.黄芪联合缬沙坦治疗糖尿病肾病及对尿亮氨酸氨基肽酶、足细胞标志蛋白水平的影响[J].中国现代医学杂志，2016，26（15）：102-105.
[10] 徐小彭，李敏雄，黄永鹏，等.纤维支气管镜联合氨溴索肺泡灌洗治疗脑梗死患者重症肺部感染伴肺不张的临床效果分析[J].中华医院感染学杂志，2016，26（12）：2697-2699.
[11] 王瑶，关鑫，臧玉娇，等.城市中老年高血压患者生命质量评价[J].公共卫生与预防医学，2017，28（4）：137-140.
[12] Solomon SD，Claggett B，McMurray JJ，et al. Combined neprilysin and renin-angiotensin system inhibition in heart failure with reduced ejection fraction： a meta-analysis [J]. Eur J Heart Fail，2016，18（10）：1238-1243.
[13] 刘诗，樊光辉.中西医结合治疗老年高血压的临床研究进展[J].中西医结合心脑血管病杂志，2013，11（7）：861-862.
[14] Ky B，Kimmel SE. Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure [J]. Circulation，2016，120（4）：310-317.
[15] 朱华军.卡托普利治疗老年高血压伴轻度肾损害的疗效及对肾功能转归的影响[J].检验医学与临床，2016，13（8）：1055-1056.
[16] Hodes AR，Tichnell C，TeRiele AS，et al. Pregnancy course and outcomes in women with arrhythmogenic right ventricular cardiomyopathy [J]. Heart，2017，102（4）：303-312.
[17] 温丽平.氨氯地平联合缬沙坦治疗老年原发性高血压合并糖尿病的疗效观察[J].中西医结合心脑血管病杂志，2016，14（10）：1146-1148.
[18] Bhat S A，Goel R，Shukla R，et al. Angiotensin receptor blockade modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation better than angiotensin-converting enzyme inhibition [J]. Mol Neurobiol，2016，53（10）：6950-6967.
[19] 林道刚.用卡托普利联合缬沙坦治疗高血压的疗效探究[J].当代医药论丛，2015，1306）：263-264.
[20] Sepp?覿 K，Hakulinen T，L?覿?覿r?覿 E，et al. Comparing net survival estimators of cancer patients [J]. Stat Med，2016，35（11）：1866-1879. |
|
|
|
