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| Effect of Tripterygium Glycosides Tablets combined with Methotrexate in treatment of rheumatoid arthritis |
| LONG Jie1 WANG Tao2 QU Chen3 ZHU Changliang4▲ |
1.Department of Nephrology and Endocrinology, the Second Affiliated Hospital of Xi′an Medical University, Shaanxi Province, Xi′an 710038, China;
2.Department of Rheumatology and Immunology, General Hospital of Chengdu Military Region, Sichuan Province, Chengdu 610083, China;
3.Department of Geriatrics, the Second Affiliated Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210000, China;
4.Department of Anesthesiology, the Second Affiliated Hospital of Air Force Medical University, Shaanxi Province, Xi′an 710038, China |
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Abstract Objective To investigate the effect of Tripterygium Glycosides Tablets combined with Methotrexate in treating rheumatoid arthritis. Methods Forty-eight patients with RA in General Hospital of Chengdu Military Region Hospital from February 2013 to September 2017 were divided into observation group (24 cases) and control group (24 cases) according to the random number table method. The control group was treated with oral Methotrexate, the observation group was treated with oral Tripterygium Polyglycoside Tablets on the basis of the treatment of the control group, both groups were treated for 6 months. The changes of clinical efficacy and symptom bodies visual analogue score (VAS), number of tender joints, number of swollen joints, and time of morning stiffness) were observed. The inflammatory indexes interleukin-6 (IL-6) and interleukin-1 (IL-1), serum tumor necrosis factor-α (TNF-α) and related biochemical index erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and rheumatoid factor (RF) anti CCP antibody, AKA positive change of patients were compared between two groups, adverse reactions occurred in both groups were recorded. Results After treatment, the total efficiency of clinical efficacy evaluation in the observation group was better than that in the control group, and the difference was statistically significant (P ＜ 0.05). Before treatment, there were no significant difference in VAS score, number of tender joints, number of swollen joints, and time of morning stiffness between the two groups (P ＞ 0.05). After treatment, VAS score, number of tender joints, number of swollen joints, and time of morning stiffness in both groups were significantly reduced compared with those before treatment, and the observation group was significantly better than the control group, with statistically significant differences (P ＜ 0.05). After treatment, the above indicators of joint inflammation and biochemical correlation were lower in both groups than before treatment, and the observation group was significantly lower than the control group, with statistically significant differences (P ＜ 0.05). After treatment, the positive rates of anti-CCP antibodies and AKA antibodies in the two groups were lower than those before treatment, and the positive rates of anti- CCP antibodies and AKA antibodies in the observation group were significantly lower than those in the control group, with statistically significant differences (P ＜ 0.05). The adverse reactions in both groups were mild and controllable, and most of them could be alleviated by symptomatic drug therapy. Conclusion Tripterygium Polyglycoside Tablets combined with Methotrexate has a good clinical effect in the treatment of RA. It can effectively inhibit the expression of RF and the levels of IL-6, IL-1, TNF-α in peripheral blood serum, reduce the inflammatory reaction, effectively alleviate and improve the clinical symptoms of RA patients, reduce the pain and the occurrence of adverse reactions, which is worthy of clinical promotion.
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