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| Effect of Zhitong Rushen Decoction on wound healing and pain degree after anal fistula operation |
| MIAO Daxing1 LAI Lei2 MIAO Chen3 |
1.Second Ward of Proctology Department, the First Affiliated Hospital to Guiyang College of Traditional Chinese Medicine, Guizhou Province, Guiyang 550002, China;
2.School of Chinese Medicine, Chongqing Medical College, Chongqing 400000, China;
3.School of Clinical Medicine, Qiqihar Medical College, Heilongjiang Province, Qiqihar 161000, China |
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Abstract Objective To investigate the effect of Zhitong Rushen Decoction on wound healing and pain degree after anal fistula operation. Methods Sixty patients with anal fistula from December 2015 to June 2018 in the First Affiliated Hospital to Guiyang College of Traditional Chinese Medicine were selected. By the random number table method all the patients were divided into control group (n = 30) and study group (n = 30). The control group was treated with Diosmin and Potassium Permanganate. The study group was treated with Zhitong Rushen Decoction on the basis of the control group, and the two groups were treated for 3 weeks. The clinical efficacy, wound healing time and disappearance time of blood in the stool, serum epidermal growth factor (EGF) and fibronectin (FN) levels, wound longitudinal diameter and wound area, symptoms (pain level, granulation morphology), wound surface exudate) integral were measured and comparedy between the two groups. Results The total effective rate of the study group was higher than that of the control group (P ＜ 0.05). The healing time of the wound in the study group and the disappearance time of blood in stool in the study group were shorter than those in the control group (P ＜ 0.05). After treatment, serum EGF and FN levels in the two groups were higher than those before treatment (P ＜ 0.01), and those in the study group were higher than those in the control group (P ＜ 0.05). After treatment, the longitudinal diameter and wound area of the two groups were smaller than those before treatment (P ＜ 0.01), and those in the study group were smaller than those in the control group (P ＜ 0.01). After treatment, scores of the pain level, granulation morphology and wound exudate in the two groups were lower than those before treatment (P ＜ 0.01), and those in the study group were lower than those in the control group (P < 0.01). Conclusion The treatment of anal fistula with Zhitong Rushen Decoction can effectively shorten the healing time of wound healing and blood in the stool, promote the disappearance of wounds, reduce the pain of patients, relieve the clinical symptoms, increase the levels of serum EGF and FN, and improve the therapeutic effect of the disease.
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