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| Clinical effect of microecologics Bifid Triple Viable Capsules on the adjuvant treatment of senile pneumonia |
| GUO Qingchun ZHANG Jiegen ZHANG Shuo SHI Na YANG Yan |
| Department of Respiratory Critical Care Medicine, Zhuozhou City Hospital, Hebei Province, Zhuozhou 072750, China |
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Abstract Objective To explore the clinical effects of microecologics Bifid Triple Viable Capsules in the adjuvant treatment of senile pneumonia. Methods The clinical data of 160 senile patients with pneumonia in Department of Respiratory Medicine of Zhuozhou City Hospital from September 2016 to October 2017 were retrospectively analyzed. Patients who were only given conventional anti-infective treatment were included in control group (80 cases). On this basis, patients who were given microecologics adjuvant therapy were included in observation group (80 cases). Serum biochemical parameters [procalcitonin (PCT), diamine oxidase (DAO), endotoxin] and cellular immune markers [CD3+, CD4+/CD8+, natural killer (NK) cell] were compared between the two groups before treatment and after 2 weeks of treatment. And the remission of clinical symptoms/signs and occurrence of adverse drug reactions were analyzed in the two groups after 2 weeks of treatment. Results After 2 weeks of treatment, the serum levels of PCT, DAO and endotoxin were significantly lower than those before treatment, and the levels in observation group were significantly lower than those in control group at the same time (P ＜ 0.05). The CD3+ levels in the two groups were not significantly different from those before treatment, and there was no statistically significant difference between the two groups (P ＞ 0.05). The levels of CD4+/CD8+ and NK cell in the two groups were significantly higher than those before treatment, and the levels in observation group were significantly higher than those in control group at the same time (P ＜ 0.05). The remission times of clinical symptoms/signs in observation group were significantly lower than those in control group (P ＜ 0.05). Within 2 weeks of treatment, the incidence rates of diarrhea, nausea and vomiting and abdominal distension in observation group were significantly lower than those in control group (P ＜ 0.05). There were no significant differences in the incidence rates of dizziness headache and itching rash between the two groups (P ＞ 0.05). Conclusion Microecologics for senile pneumonia can effectively enhance the anti-infective treatment effects, and reduce the gastrointestinal adverse reactions caused by antibiotics, and it is beneficial to the prognosis and rehabilitation of patients.
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