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Research progress on mechanism of cardiovascular ectopic calcification |
ZHAO Lei LIU Xueyuan DENG Zexi HE Jie |
Department of Geriatrics, NO.924 Hospital of People′s Liberation Army, Guangxi Zhuang Autonomous Region, Guilin 541002, China |
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Abstract Cardiovascular ectopic calcification is a pathological change closely related to clinical events and an independent risk factor of malignant cardiovascular events, its occurrence and development is an active and complex process similar to bone remodeling, including the participation of vascular smooth muscle, interstitial cell, stroma cell, the adjustment of varieties of cytokines, medium and eccrine factors, and the combined action of multiple factors, such as the intervention of fatty acid metabolism and inflammatory reaction. It has great significance of understanding its pathogenesis for preventing and stopping its progress, maintaining elderly life health, and decreasing the mortality rate of the elderly people.
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