骨刺消合剂对膝骨关节炎患者临床疗效及血清学相关指标的影响

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Abstract [Abstract] Objective To observe influence of Gucixiao Mixtures on clinical curative effect and serum superoxide dismutase (SOD), nitric oxide (NO) and tumor necrosis factor-α (TNF-α) in patients with knee osteoarthritis. Methods 60 patients with knee osteoarthritis in Orthopaedics Outpatient of Yangzhou Affiliated Hospital of Nanjing University of Traditional Chinese Medicine from January 2013 to March 2015 were selected and divided into two groups by random number table method. Patients in treatment group (n=30) received 40 mL oral Gucixiao Mixtures combined with 0.5 g centipede powder once daily after supper and discontinuation for one day per week for 5 weeks; patients in control group (n=30) received 3 tablets Jinwugutong Capsules thrice daily and discontinuation for one day per week for 5 weeks. Clinical efficacy, WOMAC score and serum SOD, NO and TNF-α before and after treatment between two groups were observed. Results Total effective rate of treatment group (90.00%) was significantly higher than that of control group (76.67%), the difference was statistically significant (P < 0.05). After treatment, WOMAC scores of treatment group and control group [pain score (2.26±1.24), (7.32±1.51) point; ankylosis score (0.51±0.28), (2.63±0.51) point; daily activity score (16.87±2.27), (30.76±4.16) point; comprehensive score (22.13±22.13), (40.81±5.32) point] were lower than those before treatment [pain score (15.46±3.23), (15.58±3.43) point; ankylosis score (6.51±1.24), (6.81±1.36) point; daily activity score (56.89±8.36), (57.41±6.55) point; comprehensive score (86.77±86.77), (84.81±9.81) point] (P < 0.05). WOMAC scores of treatment group after treatment were significantly lower than those of control group (P < 0.05). After treatment, serum SOD levels of treatment group and control group [(146.47±22.48), (126.28±19.57) U/mL] were significantly higher than those before treatment[(104.37±16.21), (105.53±14.78) U/mL], NO levels of treatment group and control group [(40.24±14.92), (49.29±16.38) μmol/L] and TNF-α levels of treatment group and control group [(54.33±17.69), (66.43±21.07) ng/L] were significantly lower than those before treatment [(57.42±21.78), (58.03±20.36) μmol/L; (97.25±32.06), (95.79±30.27) ng/L], the differences were statistically significant (P < 0.05 or P < 0.01). Serum SOD, NO and TNF-α levels after treatment between two groups were compared, the differences were statistically significant (P < 0.05). Conclusion Gucixiao Mixtures in the treatment of knee osteoarthritis have good clinical effect. It can protect the patient′s knee joint cartilage and its matrix from secondary damage, delay degeneration of knee articular cartilage, improve the nutrition and metabolism of knee joint cartilage, promote the repair of knee joint cartilage. To a certain extent, it can be prevention and treatment of knee osteoarthritis.

Key words： [Key words] Knee osteoarthritis Gucixiao Mixtures Jinwugutong Capsules Superoxide dismutase Nitric oxide Tumor necrosis factor-α

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	NIU Feng FU Qiang MA Yong LI Yaoqian

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NIU Feng FU Qiang MA Yong LI Yaoqian. Influence of Gucixiao Mixtures on clinical curative effect and serological related indicators in patients with knee osteoarthritis[J]. 中国医药导报, 2016, 13(3): 90-93.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2016/V13/I3/90

[参考文献]
[1] 申延清，刘风霞，曹红，等.膝骨关节炎患者的临床表现及相关影响因素[J].中国组织工程研究与临床康复，2011， 15（9）：1643-1646.
[2] 李宁华，张耀南，张毅，等.国内六大行政区域六城市中老年人群膝关节骨性关节炎患病危险因素比较[J].中国组织工程研究与临床康复，2007，11（39）：7758-7760.
[3] 宰庆书，蒋长伟，岳耀升，等.鲁西南邹城市膝骨性关节炎的流行病学调查及早期阶梯性治疗[J].中国组织工程研究，2015，29（19）：4610-4613.
[4] 中华医学会骨科学分会.骨关节炎诊治指南（2007年版）[J].中国临床医师杂志，2008，6（1）：28-30.
[5] Davies CM，Guilak F，Weinberg JB，et al. Reactive nitrogen and oxygen species in interleukin-1 mediated DNA damage associated with osteoarthritis [J]. Osteoarthritis Cartilage，2008，16（5）：624-630.
[6] Scott JL，Gabrielides C，Davidson RK，et al. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease [J]. Ann Rheum Dis，2010，70（8）：1502-1510.
[7] 程园园，刘健，冯云霞，等.超氧化物歧化酶在膝骨关节炎患者血清中的变化及相关因素分析[J].中国临床保健杂志，2012，15（5）：475-478.
[8] Olszewska-Sonina DM，Matewski D，Drewa G，et al. Oxidative equilibrium in the prophylaxis of degenerative joint changes：an analysis of pre-and postoperative activity of antioxidant enzymes in patients with hip and knee osteoarthritis [J]. Med Sci Monit，2010，16（5）：CR238-CR245.
[9] Mansouri FE，Chabane N，Zayed N，et al. Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes [J]. Arthritis Rheum，2011，63（1）：168-179.
[10] 林睿，高灿，胡勇挑，等.NO、TNF-α在骨性关节炎病程中的作用[J].放射免疫学，2011，24（3）：351-352.
[11] 刘晓辉，谢春意，谢获，等.探讨HMGB2、CCL1及NO在骨关节炎发病中的相关性研究[J].中国医学创新，2014， 11（9）：32-34.
[12] 陈志林，袁太珍，廖建中，等.探讨趋化因子5、白细胞介素-8及一氧化氮在骨关节炎发病中的相关性研究[J].检验医学与临床，2014，11（12）：1601-1602.
[13] 周凯，陈蕾，郎俊哲，等.抗骨增生胶囊治疗膝骨性关节炎的临床研究[J].中国临床药理学杂志，2015，31（13）：1249-1251.
[14] 范利锋，曾敬，许明军，等.中西医结合治疗膝骨关节炎的临床疗效及对IL-1和TNF-α的影响[J].湖北中医药大学学报，2014，16（5）：24-26.
[15] 金粉勤，薛锋.膝骨关节炎患者血清TNF-α与IL-6水平检测分析[J].中国实验诊断学，2014，18（3）：461-462.
[16] 邬亚军，赵治友，方琅，等.中药联合透明质酸钠治疗膝骨关节炎的临床疗效及对肿瘤坏死因子-α表达的影响[J].中国中医药科技，2014，21（2）：121-123.
[17] 牛锋，傅强，杨昌杰，等.骨刺消合剂联合玻璃酸钠关节腔注射治疗膝骨性关节炎30例临床观察[J].江苏中医药，2012，44（1）：42.
[18] 刘晓雅，王上增.补肾舒筋方内服和熏洗治疗老年早中期膝骨关节炎58例临床分析[J].中国实验方剂学杂志，2015，21（9）：204-207.
[19] 张冲，季亚成，张英泽，等.传统中医药补肾固筋方对膝骨关节炎中IL-1、TNF-α表达的影响[J].中国骨质疏松杂志，2013，19（6）：568.