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| Comparison of isobaric and hyperbaric Bupivacaine when used for spinal anesthesia in cesarean section |
| SU Zhonghong WANG Hongyu HAN Liu▲ |
| Department of Cardiovascular and Thoracic Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Jiangsu Province, Nanjing 210006, China |
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Abstract Objective To compare isobaric and hyperbaric Bupivacaine when used for spinal anesthesia in cesarean section. Methods Twenty-eight patients in Nanjing First Hospital from January to April in 2018 scheduled to receive cesarean section under spinal anesthesia were randomly allocated into two groups: group-I (isobaric Bupivacaine group) and group-H (hyperbaric Bupivacaine group) by random number table method, with fourteen cases in each group. Isobaric 0.5% Bupivacaine (0.75% Bupivacaine 2 mL diluted by cerebrospinal fluid 1 mL) 10 mg and hyperbaric 0.5% Bupivacaine (0.75% Bupivacaine 2 mL diluted by 10%GS 1 mL) 10 mg were administered for patients in group-I and group-H respectively. The mean arterial pressure (MAP), heart rate (HR), numbness level and modified Bromage score (MBS) were recorded at four time points: 1 min (T1), 5 min (T2), 10 min (T3) and 20 min (T4) after anesthesia. Hypotension and the number of phenylephrine use were recorded. Nausea and vomiting, the first time point that the ST segment began to change and the time interval between anesthesia and surgery (Ts) were also recorded. Results The numbness level was lower and MBS was higher in group-I than those in group-H significantly (P < 0.05). The HR at T1 and T3 were lower in group-I than those in group-H significantly (P < 0.05). The incidence of hypotension and number of phenylephrine use were less in group-I than those in group-H significantly (P < 0.05). The incidence of nausea was lower and the first time that the ST segment began to change was later in group-I than those in group-H significantly (P < 0.05). Conclusion Compared with hyperbaric Bupivacaine, isobaric Bupivacaine has longer onset time, lower incidence and degree of hypotension and less side effects when used for spinal anesthesia in cesarean section.
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