非酒精性脂肪性肝病不伴糖尿病患者铁负荷与病情的相关性研究

Abstract
Figure/Table
References (25)
Related Citation (8)

Download: PDF (618 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the association between iron overload and non-alcoholic fatty liver disease (NAFLD) in non-diabetic patients. Methods From January 2016 to December 2017, 152 patients with NAFLD who were not Complicated with diabetes enrolled in the Third Affiliated Hospital of Guangxi Medical University (“our hospital” for short) were selected as the observation group. Eighty healthy subjects udertaking phylical examination in our hospital were selected as the control group. Their general data, biochemical indicators, serum ferritin (SF), serum iron (SI) and serum hepcidin (HEPC) were recorded or detected, liver fat content (LFC) was evaluated by proton magnetic resonance spectroscopy. The relationships between the indexes of iron overload and other indexes were analyzed. Results SF and SI in the observation group were significantly higher than those in the control group, and HEPC was significantly lower than that in the control group, the differences were statistically significant (P ＜ 0.05). After adjustment for age and sex, both SF and SI had linear positive correlations with LFC (r = 0.461, P ＜ 0.001; r = 0.275, P = 0.001), and HEPC had a significant linear negative correlation with LFC (r = -0.479, P ＜ 0.001). The increase of SI was an independent risk factor for liver damage (OR = 1.074, P ＜ 0.05, 95%CI = 1.022-1.130). SF, SI, HEPC were weakly correlated with NAFLD activity scores (r = 0.172, P = 0.036; r = 0.192, P = 0.019; r = -0.236, P = 0.004), but the correlation coefficients were too low, which may lacked clinical significance. Conclusion Iron overload in non-diabetic patients is related to the increase of LFC and liver function damage, but it has no correlation with the degree of liver inflammation.

Key words： Non-alcoholic fatty liver disease Iron overload Liver function Iron protein

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WU Xianbin1 SU Dongxing1 LIANG Yi2 PANG Lixing1 LIANG Xiaolan1 LIU Caijin1 CHEN Qingzhou1 WEI Yujuan3 ZHANG Tingzheng4

Cite this article:

WU Xianbin1 SU Dongxing1 LIANG Yi2 PANG Lixing1 LIANG Xiaolan1 LIU Caijin1 CHEN Qingzhou1 WEI Yujuan3 ZHANG Tingzheng4. Association of iron overload with disease related indexes in non-diabetic patients with non-alcoholic fatty liver disease[J]. 中国医药导报, 2018, 15(34): 97-101.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I34/97

[1] Rinella ME. Nonalcoholic fatty liver disease：a systematic review [J]. JAMA，2015，313（22）：2263-2273.
[2] 卢慧芳，冯仲成.广宁地区非酒精性脂肪肝相关危险因素的Logistic回归分析[J].中国医学创新，2016，13（28）：67-70.
[3] 郑乐群，卢翔，张特.初诊2型糖尿病合并非酒精性脂肪肝脂肪含量的相关因素研究[J].中国现代医生，2017，55（9）：20-22，27.
[4] Park SK，Choi WJ，Oh CM，et al. Association between serum ferritin levels and the incidence of obesity in Korean men：a prospective cohort study [J]. Endocr J，2014，61（3）：215-224.
[5] 张闻平，吴静，任美杰，等.非酒精性脂肪肝病与血清铁及铁蛋白的相关性研究[J].首都医科大学学报，2015，36（5）：778-781.
[6] Utzschneider KM，Largajolli A，Bertoldo A，et al. Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women [J]. J Diabetes Complications，2014，28（2）：177-184.
[7] Parikh P，Patel J，Ingle M，et al. Serum ferritin levels predict histological severity in patients with nonalcoholic fatty liver disease in India [J]. Indian J Gastroenterol，2015，34（3）：200-208.
[8] Angulo P，George J，Day CP，et al. Serum ferritin levels lack diagnostic accuracy for liver fibrosis in patients with nonalcoholic fatty liver disease [J]. Clin Gastroenterol Hepatol，2014，12（7）：1163-1169.
[9] 中华医学会肝病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南（2010年修订版）[J].中华肝脏病杂志，2010，18（3）：163-166.
[10] 瞿欢佳，王磊，金沛桦，等.氢质子磁共振波谱在脂肪性肝病肝脏甘油三酯含量测定中的价值及其影响因素[J].中华肝脏病杂志，2017，25（11）：858-863.
[11] European Association for the Study of the Liver （EASL），European Association for the Study of Diabetes （EASD），European Association for the Study of Obesity （EASO）. EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease [J]. J Hepatol，2016，59（6）：1121-1140.
[12] 罗春华，李国静，周军，等.宜昌市职业人群非酒精性脂肪性肝病流行病学调查及其与代谢综合征相关性研究[J].重庆医学，2016，45（3）：390-392.
[13] 曹一显，李良平.非酒精性脂肪性肝炎与内皮功能异常和动脉粥样硬化的关系[J].中华肝脏病杂志，2014，22（3）：205-208.
[14] 吴玉梅.上海市某疗养院体检人群体重指数与血脂水平及非酒精性脂肪肝关系的调查研究[J].中国现代医生，2017，55（30）：121-123，130.
[15] 张富春，曾庆新.非酒精性脂肪肝患者血浆Fetuin-A表达对动脉粥样硬化与心血管事件发生的影响研究[J].中国医学创新，2017，14（31）：44-47.
[16] 梅歆.2型糖尿病合并非酒精性脂肪肝与颈动脉粥样硬化关系的研究[J].中国医学创新，2016，13（26）：112-115.
[17] 张梅，薛亚妮，冯旭霞.胰岛素与胰岛素促泌剂对2型糖尿病合并非酒精性脂肪肝的影响[J].中国医药导报，2016，13（11）：138-141.
[18] 莫小庆，黄春，宋青青，等.2型糖尿病伴非酒精性脂肪肝患者胱抑素C与胰岛素抵抗的相关性研究[J].中国医药导报，2017，14（24）：78-80.
[19] Li J，Cao Y. Serum ferritin as a biomarker for diabetes and insulin resistance：a further study [J]. Acta Diabetol，2015，52（2）：417-419.
[20] 刘志平，张金华.非酒精性脂肪性肝病患者胰岛素抵抗与血清铁蛋白、γ-谷氨酰转肽酶的关系[J].胃肠病学和肝病学杂志，2015，24（8）：917-919.
[21] 欧强，王洋，徐燕华，等.非酒精性脂肪性肝病患者血清铁代谢指标的变化及临床意义[J].临床肝胆病杂志，2016，32（12）：2360-2363.
[22] 张林杉，卞华，颜红梅，等.2型糖尿病患者铁负荷与非酒精性脂肪性肝病的相关性研究[J].中华内分泌代谢杂志，2014，30（1）：8-12.
[23] Kowdley KV，Belt P，Wilson LA，et al. Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease [J]. Hepatology，2012，55（1）：77-85.
[24] Nelson JE，Wilson L，Brunt EM，et al. Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease [J]. Hepatology，2011，53（2）：448-457.
[25] 沈洁，蔡静明，孙梦云，等.铁超载对非酒精性脂肪肝病HepG2细胞模型中Hepcidin和 Fpn-1的影响[J].癌变·畸变·突变，2017，29（3）：184-188.