miRNAs在肝细胞癌中的功能及应用前景

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Abstract Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver and is one of the leading causes of cancer deaths in the world, it is characterized by a poor prognosis. More and more researches have focused on finding new molecular markers for HCC diagnosis and prognosis. microRNAs (miRNAs) is a sort of small and non-coding RNA. Deregulated miRNAs themselves act as oncogenes or tumor suppressor genes and are involved in the development and progression of cancer. Recent studies have found that the abnormal expression of many miRNAs is involved in many biological processes of HCC. This paper summarizes the studies on the role of miRNAs in the development and progression of HCC tumors in recent years, and provides a theoretical basis for the application of miRNAs in HCC diagnosis, prognosis or as a therapeutic target.

Key words： microRNAs Hepatocellular carcinoma Diagnosis Treatment

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	CHEN Caixia SU Xiulan

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CHEN Caixia SU Xiulan. The function and application prospect of miRNAs in hepatocellular carcinoma[J]. 中国医药导报, 2018, 15(34): 37-40,48.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I34/37

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