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| The research progress on the pain treatment with Vitamin C |
| LIU Yao1 XIONG Miaomiao1 CHEN Yajie1 JIN Jun1 SHEN Wen2▲ |
1.Key Laboratory of Anesthesiology, Xuzhou Medical University, Jiangsu Province, Xuzhou 221004, China;
2.Department of Pain Management, Affiliated Hospital of Xuzhou Medical University, Jiangsu Province, Xuzhou 221002, China |
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Abstract Vitamin C (VitC), also known as ascorbic acid, is a highly effective antioxidant in the human body and plays an important role in many biosynthetic processes. VitC deficiency is highly prevalent in a variety of patients, such as patients with trauma, infection, and cancer. Many recent clinical studies have shown that intravenous high-dose VitC can prevent the occurrence of complex regional pain syndrome after fracture. It can also relieve the herpes zoster pain and reduce the incidence of postherpetic neuralgia. In addition, the high-dose VitC can reduce pain in patients with advanced cancer and extend their survival time. Many experts have proposed several mechanisms for relieving pain in VitC, but they are still controversial. All in all, VitC has shown a safe and effective effect in relieving acute and chronic pain.
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[1] Amanda，C.de，C.Williams，等.疼痛新定义[J].中国疼痛医学杂志，2016（11）：808-809.
[2] Crowe M，Whitehead L，Seaton P，et al. Qualitative meta-synthesis：the experience of chronic pain across conditions [J]. Jadv Nurs，2016，73（5）：1004-1016.
[3] 杨淑梅，杨晓梅.维生素C的研究动态及新的治疗前景[J].中国医药导报，2008，5（28）：11-13.
[4] Fukushima R，Yamazaki E. Vitamin C requirement in surgical patients [J]. Curr Opin Clin Nutr，2010，13（6）：669-76.
[5] Carr AC，Shaw GM，Fowler AA，et al. Ascorbate-dependent vasopressor synthesis：A rationale for vitamin C administration in severe sepsis and septic shock? [J]. Crit Care，2015，19（1）：418.
[6] 庄守纲，郝继英，王质刚.慢性肾衰血透患者血清维生素C水平的观察[J].北京生物医学工程，1992，11（1）：44-45.
[7] Mayland CR，Bennett MI，Allan K. Vitamin C deficiency in cancer patients [J]. Palliative Med，2005，19（1）：17.
[8] 范逢吉，白赫南，赵云志.人视网膜色素上皮细胞氧化应激损伤模型的建立以及维生素C保护作用的观察研究[J].临床和实验医学杂志，2018，17（19）：2056-2060.
[9] 陈国烽，王亚军.维生素C在新陈代谢中的生理功能[J].中国食物与营养，2014，20（1）：71-74.
[10] Dionne CE，Laurin D，Desrosiers T，et al. Serum vitamin C and spinal pain： a nationwide study [J]. Pain，2016， 157（11）：2527-2535.
[11] Shibuya N，Humphers JM，Agarwal MR，et al. Efficacy and safety of high-dose vitamin C on complex regional pain syndrome in extremity trauma and surgery--systematic review and meta-analysis [J]. J Foot Ankle Surg，2013， 52（1）：62-66.
[12] Zollinger PE，Tuinebreijer WE， Kreis RW，et al. Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures：a randomised trial [J]. Lancet，1999， 354（9195）：2025-2028.
[13] 郝鹏，杜传超，程华，等.维生素C对复杂性区域疼痛综合征预防效果的Meta分析[J].创伤外科杂志，2016，18（10）：595-598.
[14] 温博，曾升平.类风湿关节炎的研究进展[J].世界中西医结合杂志，2014，9（9）：1014-1016.
[15] Lunec J，Blake DR. The determination of dehydroascorbic acid and ascorbic acid in the serum and synovial fluid of patients with rheumatoid arthritis （RA） [J]. Free Radical Res Com，1985，1（1）：31-39.
[16] Aghajanian P，Hall S，Wongworawat MD，et al. The Roles and Mechanisms of actions of vitamin c in bone：new developments [J]. J Bone Miner Res，2015，30（11）：1945-55.
[17] Jeon YH. Herpes zoster and postherpetic neuralgia：practical consideration for prevention and treatment [J]. Korean J Pain，2015，28（3）：177-184.
[18] Chen JY，Chu CC，So EC，et al. Treatment of postherpetic neuralgia with intravenous administration of vitamin C [J]. Anesth Analg，2006，103（6）：1616.
[19] Schencking M，Sandholzer H，Frese T. Intravenous administration of vitamin C in the treatment of herpetic neuralgia： two case reports [J]. Med Sci Monitor，2010， 16（5）：CS58.
[20] Byun SH，Jeon Y. Administration of Vitamin C in a Patient with Herpes Zoster—A case report[J]. Korean J Pain，2011，24（2）：108-111.
[21] Min SK，Dong JK，Chan HN，et al. A study of intravenous administration of vitamin c in the treatment of acute herpetic pain and postherpetic neuralgia [J]. Ann Dermatol，2016，28（6）：677.
[22] Mikirova N，Casciari J，Riordan N，et al. Clinical experience with intravenous administration of ascorbic acid： achievable levels in blood for different states of inflammation and disease in cancer patients [J]. J Transl Med，2013，11（1）：191.
[23] Mamede AC，Tavares SD，Abrantes AM，et al. The role of vitamins in cancer：a review [J]. Nutr Cancer，2011，63（4）：479-494.
[24] 王亚萍，陈锴，刘晓斌，等.氧化苦参碱联合维生素C抑制胃癌细胞增殖的研究进展[J].中国医药导报，2017， 14（3）：52-55.
[25] 刘宪凯，吕国庆，杨满，等.来那度胺、三氧化二砷及维生素C治疗复发/难治性多发性骨髓瘤的疗效分析[J].中国现代医生，2018，56（2）：16-19.
[26] Heaney ML，Gardner JR，Karasavvas N，et al. Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs [J]. Cancer Res，2008，68（19）：8031.
[27] Fruehauf JP，Meyskens FL. Reactive oxygen species：A breath of life or death? [J]. Clin Cancer Res，2007，13（3）：789-794.
[28] Padayatty SJ，Riordan HD，Hewitt SM，et al. Intravenously administered vitamin C as cancer therapy：three cases [J]. Can Med Assoc J，2006，174（7）：937.
[29] 董文芳，陆建华.术后急性疼痛与慢性疼痛关系的研究进展[J].国际麻醉学与复苏杂志，2015，36（1）：78-81.
[30] 薛照静，黄宇光，赵晶，等.慢性术后疼痛研究进展[J].中国疼痛医学杂志，2013，19（11）：685-689.
[31] Kanazi GE，Elkhatib MF，Yazbeckkaram VG，et al. Effect of vitamin C on morphine use after laparoscopic cholecystectomy：a randomized controlled trial [J]. Can J Anaesth，2012，59（6）：538-543.
[32] Jeon Y，Park JS，Moon S，et al. Effect of Intravenous high dose vitamin c on postoperative pain and morphine use after laparoscopic colectomy：a randomized controlled trial [J]. Pain Res Manag，2016，2016（5）：9 147 279.
[33] Ayatollahi V，Dehghanpoor-Farashah S，Behdad S，et al. Effect of intravenous vitamin C on post-operative pain in uvulopalatopharyngoplasty with tonsillectomy [J]. Clin Otolaryngol，2016，42（1）：139-143.
[34] Kim HK，Park SK，Zhou JL，et al. Reactive oxygen species （ROS） play an important role in a rat model of neuropathic pain [J]. Pain，2004，111（1-2）：116.
[35] May JM，Qu ZC，Nazarewicz R，et al. Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine [J]. Brain Res Bull，2013，90（1）：35-42.
[36] Wu CM，Lin MW，Cheng JT，et al. Regulated， electroporation-mediated delivery of pro-opiomelanocortin gene suppresses chronic constriction injury-induced neuropathic pain in rats [J]. Gene Ther，2004，11（11）：933.
[37] Mikirova N，Hunninghake R. Effect of high dose vitamin C on Epstein-Barr viral infection [J]. Med Sci Monitor，2014，20（20）：725-732.
[38] Pe?觡a DLVL，Lieske JC，Milliner D，et al. Urinary oxalate excretion increases in home parenteral nutrition patients on a higher intravenous ascorbic acid dose [J]. Jpen J Parenteral En，1900，29（6）：435.
[39] 许婧，刘京铭，付雷，等.大剂量应用维生素C治疗相关疾病安全性的系统评价[J].中国药房，2015（9）：1229-1233. |
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