肥胖儿童脂肪组织内质网应激促动脉粥样硬化研究进展

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Abstract Cardiovascular disease is the most serious public health problem that currently threatens the health of people in our country. Atherosclerosis is the main pathological basis and can occur in childhood, and the risk of obesity in children is increasing. Endoplasmic reticulum stress is an important mechanism for the development of atherosclerosis. Macrophage infiltration in obese adipose tissue increases, endoplasmic reticulum stress aggravates, interaction between adipocytes and macrophages accelerates atherosclerotic progression, which plays an important role in the development of atherosclerotic cardiovascular disease. For deepening people′s knowledge of obesity accelerating atherosclerosis and raising awareness of preventing childhood obesity, and exploiting new ideas for treating atherosclerosis in children with obesity, this review introduced the relationship between endoplasmic reticulum stress of adipose tissue and the development of atherosclerosis in children with obesity.

Key words： Childhood obesity Adipose tissue Endoplasmic reticulum stress Atherosclerosis Cardiovascular disease

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	WANG Mingxia JIA Lihong ZHAI Lingling WEI Wei SUN Qi BAI Yinglong

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WANG Mingxia JIA Lihong ZHAI Lingling WEI Wei SUN Qi BAI Yinglong. Research progress on atherosclerosis promoted by endoplasmic reticulum stress of adipose tissue in children with obesity[J]. 中国医药导报, 2018, 15(32): 24-27.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I32/24

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