糖皮质激素联合丙种球蛋白对小儿肺炎的影响

Abstract
Figure/Table
References (30)
Related Citation (4)

Download: PDF (582 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To approach influence of glucocorticoid combined with immunoglobulin on infantile pneumonia. Methods The clinical data of 100 cases of infantile pneumonia in Department of Pediatrics of Yan'an People′s Hospital from January 2015 to January 2018 were retrospectively analyzed, and they were divided into control group and observation group by different treatment methods, with 50 cases in each group. The children with pneumonia of two groups were treated with anti-inflammatory, atomized and antitussive therapy, the control group was given intravenous injection of gamma globulin in addition, and the observation group was given intravenous injection of methylprednisolone on the basis of the control group. The changes of WBC, C-reactive protein, procalcitonin of two groups before and after treatment were observed. The antifebrile time, cough time, hello time, shadow absorption time, hospital stays, and clinical treatment total effective rate of two groups were observed. Results The WBC, C-reactive protein and procalcitonin of two groups before treatment were compared, the differences were no statistical significance (P > 0.05). After treatment, the WBC, C-reactive protein, procalcitonin of two groups were lower than the those before treatment, and those of the observation group were lower than the control group, the differences were statistical significance (P < 0.05). The antifebrile time, cough suppressant time, rale disappear time, chest shadow absorption time and hospital stays of observation group were shorter than those of the control group, the differences were statistical significance (P < 0.05). The treatment total effective rate of the observation group was higher than that of the control group, the difference was statistical significance (P < 0.05). Conclusion The glucocorticoid combined with immunoglobulin in the treatment of infantile pneumonia, can decrease serum inflammatory markers, shorten clinical symptom improvement time, improve clinical treatment result.

Key words： Glucocorticoid Immunoglobulin Infantile pneumonia Total effective rate

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHOU Jinfang ZHANG Yanfeng▲

Cite this article:

ZHOU Jinfang ZHANG Yanfeng▲. The influence of glucocorticoid combined with immunoglobulin on infantile pneumonia[J]. 中国医药导报, 2018, 15(27): 86-89.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I27/86

[1] 薛飞，汪受传.糖皮质激素联合丙种球蛋白对小儿肺炎临床症状和炎症指标的影响[J].中国中西医结合儿科学，2018，10（2）：93-95.
[2] Lee SC，Youn YS，Rhim JW，et al. Early serologic diagnosis of my coplasma pneumoniae pneumonia：an observational study on changes in titers of specific-IgM antibodies and cold agglutinins [J]. Medicine （Baltimore），2016， 95（19）：e3605．
[3] 张祥.糖皮质激素治疗难治性肺炎支原体肺炎的临床观察[J].临床肺科杂志，2015，20（8）：1472-1475.
[4] Jiang F，He J，Navarro-Alvarez N，et al. Elongation Factor Tu and Heat Shock Protein 70 are membrane-associated proteins from Mycoplasma ovipneumoniae Capable of inducing strong immune response in mice [J]. PLoS One，2016，11（8）：e0161170．
[5] 徐湘，周春，胡磊.阿奇霉素序贯疗法联合糖皮质激素治疗小儿肺炎支原体肺炎的疗效及对血清补体、Clara细胞分泌蛋白表达的影响[J].广西医学，2018，40（7）：839-841.
[6] 沈晓明，王卫平.儿科学[M].7版．北京：人民卫生出版社，2008：280.
[7] 沈安英，张建华，全彩琪.阿奇霉素联合雾化吸入治疗肺炎支原体肺炎疗效观察[J].临床肺科杂志，2014，19（2）：236-239．
[8] Ishiguro N，Koseki N，Kaiho M，et al. Sensitivity and Specificity of a Loop-mediated isothermal amplification assay for the Detection of Mycoplasma Pneumonia from nasopharyngeal swab samples compared with those of Real-time PCR [J]. Clin Lab，2015，61（5-6）：603-606．
[9] 方丹枫.阿奇霉素联合小剂量糖皮质激素治疗儿童大叶性肺炎的临床疗效[J].中国妇幼保健，2018，33（1）：127-128.
[10] Guo WL，Wang J，Zhu LY，et al． Differentiation between Mycoplasma and viral community-acquired pneumonia in children with lobe or multi foci infiltration：a retrospective case study [J]. BMJ Open，2015，5（1）：e006766．
[11] 楚玉波.糖皮质激素治疗儿童肺炎支原体大叶性肺炎的价值[J].河北医药，2018，40（7）：1077-1079.
[12] 林远福.多巴胺联合西地兰治疗小儿肺炎合并心力衰竭的效果观察[J].中外医学研究，2017，14（33）：30-32.
[13] 赵昱.盐酸氨溴索雾化吸入辅助治疗小儿肺炎的临床效果分析[J].中外医学研究，2017，14（3）：100-101.
[14] Odeh AN，Simecka JW．Regulatory CD+4CD+25 T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pne-umonia and Promote IL-17 and IFN-γ Responses [J]. PLoS One，2016，11（5）：e0155648.
[15] 满素贞.酚妥拉明联合小剂量多巴胺治疗小儿肺炎效果分析[J].中外医学研究，2018，14（1）：18-20.
[16] 梅玉霞.抗生素联合糖皮质激素治疗重症支原体肺炎对患儿临床症状、炎性指标和细胞免疫的影响[J].河北医药，2016，38（6）：883-885.
[17] Sato T，Okamura T，Kojima-Shibata C，et al． Correlated response of peripheral blood cytokines with selection for reduced mycoplasma pneumonia of swine lesions in Landrace pigs [J]. Anim Sci J，2015，87（4）：477-483．
[18] 林志雄，王开梅，陈江，等.不同剂量糖皮质激素辅助治疗小儿难治性肺炎支原体肺炎合并肺外并发症疗效比较[J].中国医院药学杂志，2017，37（7）：639-642.
[19] Bai F，Ni B，Liu M，et al． Mycoplasma hyopneumoniae-derived lipid-associated membrane proteins induce inflammation and apoptosis in porcine peripheral blood mononuclear cells in vitro [J]. Vet Microbiol，2015，175（1）：58－67．
[20] 于洋，范捷.糖皮质激素联合抗生素对重症肺炎患者血清感染指标、急性蛋白及应激激素的影响[J].海南医学院学报，2017，23（20）：2765-2767，2771.
[21] Catanzaro JM，Hueston CM，Deak MM，et al． The impact of the P2X7 receptor antagonist A-804598 on neuroimmune and behavioral consequences of stress [J]. Behav Pharmacol，2014，25（5-6）：582-598．
[22] 梁敏，杨芳，杨方政，等.干扰素联合丙种球蛋白对儿童传染性单核细胞增多症的疗效评价[J].西部医学，2016，（5）：681-683.
[23] 汤勉，邱燕玲，韩鹏.阿奇霉素联合糖皮质激素治疗小儿大叶性肺炎临床效果及对血清CRP、IL-6和PCT水平的影响[J].河北医药，2017，39（15）：2278-2280， 2284.
[24] 李里力，曹晓莉.糖皮质激素辅助治疗对大叶性肺炎小儿血清CRP、IL-6及PCT水平影响研究[J].中国生化药物杂志，2016，36（2）：48-50．
[25] Patel K，Ali N，Nazir H，et al. Mycoplasma pneumonia as Cause of acute respiratory distress syndrome（ARDS）and diffuse alveolar hemorrhage （DAH） requiring veno-venous extra corporeal membrane oxygenation（VV-ECMO） [J]. Chest，2014，146（4）：163A．
[26] Yamada K，Yanagibara K，Kaku N，et al. Azitbromycin attenuates lung inflammation in a mouse model of ventilator-as-sociatedpneumonia by multidrug-resistant Acinetobacter baumannii [J]. Antimicrob Agents Chemother，2013，57（8）：3883-3888.
[27] Berti E，Sollai S，Orlandini E，et al. Analysis of measles-related hospitalizations in tuscany from 2000 to 2014 [J]. Epidemiol infect，2016，144（12）：2605-2612.
[28] Tu B，Zhao JJ，Hu Y，et al. Clinical and immunological analysis of measles patients admitted to a Beijing hospital in 2014 during an outbreak in China [J]. Epidemiol infect，2016，144（12）：2613-2620.
[29] Jackson DJ，Gangnon RE，Evans MD，et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children [J]. Am J Respir crit Care Med，2008，178（7）：667-672.
[30] 王馨平，吴昭萍，李光清，等.雾化吸入布地奈德联合口服泼尼松治疗嗜酸细胞性支气管炎的临床效果[J].中国医药，2017，12（12）：1822-1826.