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| Effect of Yangxin Dingji Capsules on related hormone and neurotransmitter in patients with perimenopausal syndrome |
| ZHANG Zi1 LIU Na2 LIU Dongsheng2 |
1.Department of Traditional Chinese Medicine, the Third Hospital of Shijiazhuang City, Hebei Province, Shijiazhuang 050000, China;
2.Department of Cardiology, Cangzhou People′s Hospital, Hebei Province, Cangzhou 061000, China |
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Abstract Objective To discuss the effect of Yangxin Dingji Capsules on clinical symptoms, related hormone and neurotransmitter in patients with perimenopausal syndrome. Methods From November 2014 to July 2016, 104 patients with perimenopausal syndrome treated in the Third Hospital of Shijiazhuang City were divided into control group and study group by random number table, with 52 cases in each group. Patients in control group were treated with Nilestriol, patients in the study group were treated with Yangxin DingJi Capsules and Nilestriol. Treatment lasts for 4 weeks. Before and after treatment, clinical effects were compared between two groups. Kupper-man score, menopause rating scale (MRS), self-rating depression scale (SDS), and serum estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), 5-hydroxytryptamine (5-HT), norepinephrine (NE) and dopamine (DA) levels of the patients in two groups were measured. Adverse reactions were recorded in two groups. Results The total effective rate in study group was 90.38%, which was significantly higher than those in control group (P < 0.05). Compared with before treatment, the Kupper-man, MRS, SDS scores of the two groups were significantly lower after treatment, and the study group was significantly lower than that in control group (P < 0.01); the level of E2 was significantly higher, levels of FSH and LH were significantly decreased, and the study group improved more significantly (P < 0.01); the levels of 5-HT, NE and DA increased significantly, and that in study group was significantly higher than in control group (P < 0.01). Conclusion Yangxin Dingji Capsules can significantly improve the clinical symptoms, hormone and neurotransmitter levels of patients with perimenopausal syndrome and high security.
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