|
|
|
| The level changes of tau protein, activin A, neuro-specific enolase and its clinical significance in premature infants with hypoxic ischemic encephalopathy |
| JIANG Tingting1 WANG Wei2 GAO Jisheng2 LIU Gang2 |
1.Department of Child Healthcare, Xuzhou Children′s Hospital, Jiangsu Province, Xuzhou 221006, China;
2.Department of Neonatology, Xuzhou Children′s Hospital, Jiangsu Province, Xuzhou 221006, China |
|
|
|
Abstract Objective To study the level changes of tau protein, activin A, neuro-specific enolase (NSE) in premature infants with hypoxic ischemic encephalopathy, and to analyze its clinical significance. Methods The total of 131 cases of hypoxic ischemic encephalopathy treated in Xuzhou Children′s Hospital from February 2016 to December 2017 were selected as the study group, 100 cases of premature infants without hypoxic ischemic encephalopathy at the same period were selected as the control group. The serums tau protein, activin A and NSE levels of postnatal 7 d infants in two groups were compared. The preterm infants in the study group were divided into mild group (32 cases), moderate group (61 cases) and severe group (38 cases) according to the severity of the disease. The serum levels of tau protein, activin A, NSE and neonatal neurobehavioral (NBNA) score in postnatal 7 d infants with different severity was compared. The correlation between NBNA score, serum tau protein, activin A and NSE level was also analyzed. Results The levels of serum tau protein, activin A and NSE in preterm infants of the study group were significantly higher than those of the control group, the differences were statistically significant (all P < 0.01). Serum tau protein and activin A and NSE levels of mild group, moderate group and severe group showed a rising trend, the differences between groups were statistically significant (all P < 0.01). The NBNA score in the preterm 7 d infants of severe group was significantly lower than that of the moderate group and mild group, while the moderate group was significantly lower than that of the mild group, the differences between the groups were statistically significant (P < 0.05). Pearson correlation analysis showed that serum tau protein, activin A and NSE levels in premature infants with hypoxic ischemic encephalopathy were negatively correlated with NBNA scores (r = -0.612, -0.583, -0.648, all P < 0.05); the level of serum tau protein in premature infants with hypoxic ischemic encephalopathy was positively correlated with the levels of activin A and NSE (r = 0.531, 0.487, all P < 0.05); serum activin A was positively correlated with NSE level (r = 0.443, P < 0.05). Conclusion The serum tau protein, activin A and NSE of hypoxic-ischemic encephalopathy are highly expressed, and are closely related to the neural development of premature infants.
|
|
|
|
|
|
[1] Paneth N. Hypoxia-ischemia and brain injury in infants born preterm [J]. Dev Med Child Neurol，2018，60（2）：115.
[2] 钟明，肖善秋，朱传瑞，等.神经节苷酯辅助亚低温治疗早产儿缺氧缺血性脑病的疗效观察[J].临床医学工程，2017，24（2）：178-180.
[3] 裘品丹，李志林，翁纽周，等.颅脑超声对早产儿缺氧缺血性脑病的临床应用价值[J].现代医用影像学，2017，26（2）：461-464.
[4] 张延义.神经节苷脂联合纳洛酮治疗中重度新生儿缺氧缺血性脑病55例效果分析[J].中国现代医生，2014，52（16）：61-62.
[5] 张沂洁，王来栓.亚低温治疗对缺氧缺血性脑病新生儿生理学指标和药物代谢的影响[J].中华围产医学杂志，2013，16（12）：725-730.
[6] 中华医学会儿科学分会新生儿学组．新生儿缺氧缺血性脑病诊断标准[J].中华儿科杂志，2005，43（8）：584．
[7] 张雪雁，李军.新生儿缺氧缺血性脑病分度与磁敏感加权成像出血检出率的相关性研究[J].磁共振成像，2014， 5（3）：166-169.
[8] Liao W，Xu H，Ding J，et al. Mild hypothermia therapy for moderate or severe hypoxicischemic encephalopathy in neonates [J]. Iran J Public Health，2018，47（1）：64-69.
[9] 覃桂锋，王娜，程文娟，等.神经节苷脂联合高压氧治疗新生儿缺血缺氧性脑病的临床有效性观察[J].中国医学创新，2017，14（14）：86-88.
[10] 古文熠，朱培贵，邹其源，等.分析比较CT及MRI在新生儿缺氧缺血性脑病诊断中价值[J].中华临床医师杂志：电子版，2016，10（10）：1494-1497.
[11] 肖爱娇，汪建民，刘结民，等.缺氧缺血性脑病新生小鼠脑组织pCaMKⅡα表达和空间学习记忆的变化[J].中华行为医学与脑科学杂志，2017，26（3）：193-197.
[12] Ye Q，Wu Y，Wu J，et al. Neural stem cells expressing bFGF reduce brain damage and restore sensorimotor function after neonatal hypoxia-ischemia [J]. Cell Physiol Biochem，2017，45（1）：108-118.
[13] 卢雨欣，江雯，林艳，等.血清tau蛋白水平与新生儿缺血缺氧性脑病的严重程度并与神经发育预后相关研究[J].中国儿童保健杂志，2015，23（11）：1142-1146.
[14] 索有梅，辛颖.早产儿缺氧缺血性脑病与血清Tau蛋白及NSE的相关性研究[J].中国优生优育，2014，20（6）：393-395.
[15] 古力娜·艾沙，刘淑萍.内源性激活素A水平变化与窒息新生儿致缺氧缺血性脑病的相关性分析[J].中国医师杂志，2016，18（6）：894-896.
[16] 耿淑霞，朱君丽，田婷，等.Tau蛋白在早产儿缺氧缺血性脑病中的表达意义[J].中国妇幼保健，2016，31（18）：3515-3517.
[17] 石境懿，夏利，张衡，等.rhu-EPO辅助治疗对新生儿缺氧缺血性脑病氧化应激损伤及Caspase-3、ACT A水平的影响[J].河北医科大学学报，2017，38（11）：1295-1299.
[18] 茅利明，单平囡.NSE在外科病人血清中值的异常变化及意义探讨[J].浙江创伤外科，2018，23（2）：221-223.
[19] 许晓琳，李琛，孙玉敏，等.病毒性脑炎患儿脑脊液和血清中NSE、CK-BB、LDH的变化及相关性研究[J].临床和实验医学杂志，2017，16（2）：151-154.
[20] Wu Z，Zhang M，Zhang Z，et al. Ratio of β-amyloid protein （Aβ） and Tau predicts the postoperative cognitive dysfunction on patients undergoing total hip/knee replacement surgery [J]. Exp Ther Med，2018，15（1）：878-884.
[21] 耿淑霞.缺氧缺血性脑病早产儿血清tau蛋白、ACTA、NSE水平与神经发育的关系[J].山东医药，2017，57（44）：53-55. |
|
|
|
