|
|
|
| Correlation analysis between brain parenchymal changes and cognitive dysfunction in children with type 1 diabetes mellitus |
| ZHU Chen XUN Chong▲ ZHANG Xiaojun ZHANG Xinrong |
| Department of Radiology, the Affiliated Children's Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210000, China |
|
|
|
Abstract Objective To study the effect of type 1 diabetes (T1D) on the brain parenchyma changes and cognitive function in children. Methods Forty children with T1D admitted in the Department of Childhood Endocrinology and Metabolism, the Affiliated Children′s Hospital of Nanjing Medical University (“our hospital” for short) from January to December 2017 were included as the T1D group. Another 40 children examined in our hospital for physical examination were involved in non T1D group. Both groups were detected blood HbA1c before and after MRI. All children enrolled in the study were underwent IQ tests and evaluated brain developmental-related scores by professionals. Resting state functional magnetic resonance (rsfMRI) scans were performed on both groups. The rsfMRI data were preprocessed by SPM8 software, and the seed connection ICA analysis was performed by GIFT software. Pearson correlation test was used to analyze the correlation. Results There was no significant difference in IQ levels between the two groups (P ＞ 0.05). For the brain performance, learning, memory and treatment ability, the scores of children with T1D were lower than those in non T1D group, but there was no significant difference (P ＞ 0.05), considering lack of samples and/or young age. The brain connections in the T1D group increased, including the left frontal lobe, the left anterior wedge anterior, the right cerebellum and the left anterior superior gyrus. There was no correlation between these abnormal connections and HbA1c level, brain cognitive function (P ＞ 0.05). Conclusion The connections of brain regions in children with T1D increase, but there is no significant correlation between HbA1c level, cognitive function and these abnormal connections. It may be related to the factors such as small sample size and short observing time.
|
|
|
|
|
|
[1] Liu W，Yang X，Huang J. Efficacy and Safety of Insulin Degludec versus Insulin Glargine：A Systematic Review and Meta-Analysis of Fifteen Clinical Trials [J]. Int J Endocrinol，2018：https://doi.org/10.1155/2018/8726046.
[2] Candido R，Wyne K，Romoli E. A Review of Basal-Bolus Therapy Using Insulin Glargine and Insulin Lispro in the Management of Diabetes Mellitus [J]. Diabetes Ther，2018， 9（3）：927-949.
[3] Dawoud D，O'Mahony R，Wonderling D，et al. Basal Insulin Regimens for Adults with Type 1 Diabetes Mellitus：A Systematic Review and Network Meta-Analysis [J]. Value Health，2018，21（2）：176-184.
[4] Kawasaki M，Arata N，Miyazaki C，et al. Obesity and abnormal glucose tolerance in offspring of diabetic mothers：A systematic review and meta-analysis [J]. PLoS One，2018，13（1）：e0190676.
[5] Zhou Y，Lian S，Zhang J，et al. Mitochondrial Perturbation Contributing to Cognitive Decline in Streptozotocin-Induced Type 1 Diabetic Rats [J]. Cell Physiol Biochem，2018， 46（4）：1668-1682.
[6] Cumba-Avilés E. Cognitive-Behavioral Group Therapy for Latino youth with Type 1 Diabetes and depression：A case study [J]. Clin Case Stud，2017，16（1）：58-75.
[7] Seke Etet PF，Farahna M，Satti GMH，et al. Garcinia kola seeds may prevent cognitive and motor dysfunctions in a type 1 diabetes mellitus rat model partly by mitigating neuroinflammation [J]. J Complement Integr Med，2017，14（3）：doi：10.1515/jcim-2016-0167.
[8] Wei C，Allen RJ，Tallis PM，et al. Cognitive behavioural therapy stabilises glycaemic control in adolescents with type 1 diabetes-Outcomes from a randomised control trial [J]. Pediatr Diabetes，2018，19（1）：106-113.
[9] 曹顺顺，胡杨杨.1型糖尿病儿童晚期糖基化终末产物、血清抗苗勒管激素和抑制素B对儿童生殖器官发育影响的研究[J].医学研究杂志，2017，46（12）：116-118.
[10] 蔡芸莹，苏恒.1型糖尿病的非胰岛素治疗[J].国际内分泌代谢杂志，2015，2（6）：388-391.
[11] 曾冬阳，张彩虹，张华，等.青少年1型糖尿病患儿对疾病认知和体验的质性研究[J].中国实用护理杂志，2017， 3（29）：2276-2279.
[12] 张峥，张兆辉.阿尔茨海默病与2型糖尿病的相关性研究进展[J].卒中与神经疾病，2018，25（1）：112-117.
[13] 孙厦厦，王爱民，王君.1型糖尿病患儿家长低血糖认知状况及影响因素分析[J].护理学杂志，2016，31（9）：35-37.
[14] 王伶杰，张洧，李映凯，等.交叉性失语语言功能重组的功能磁共振研究[J].中国老年学杂志，2017，37（20）：5007-5010.
[15] 王海楠，毕馨文，江晓菁.七氟烷预处理对1型糖尿病大鼠术后认知功能的影响[J].中国医药，2017，21（9）：1360-1363.
[16] 马文玲，郭顺林，魏柯香，等.功能磁共振成像技术在肝脏的应用现状[J].磁共振成像，2017，8（11）：866-870.
[17] 杨锐，闵朋.帕金森病患者静息态功能磁共振的临床应用价值分析[J].中国CT和MRI杂志，2017，15（10）：7-9.
[18] 蒋欣，尹春丽，滕振杰，等.静息态功能磁共振在皮质下缺血性血管性认知损害中的应用[J].国际脑血管病杂志，2016，24（5）：454-458.
[19] 张斌，张杰文，张淑玲，等.正常人汉字工作记忆功能磁共振脑激活区改变的研究[J].中国实用神经疾病杂志，2017，20（19）：5-9.
[20] 张明哲，孙昭胜，郭洪，等.创伤性脑损伤昏迷患者默认网络功能连接的静息态fMRI研究[J].河北医学，2016， 22（3）：383-387.
[21] 白伟，郭炜，陈自谦.2型糖尿病视网膜病变患者脑自发神经活动的静息态功能磁共振研究[J].医学影像学杂志，2018，28（2）：191-195.
[22] 宫媛媛，王军，潘惠惠，等.偏头痛静息态fMRI的研究进展[J].中国当代医药，2016，23（15）：13-15，19. |
|
|
|
