高尿酸血症史对糖尿病人群归因危险度的分析

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Abstract Objective To investigate the effect of hyperuricemia on diabetes attack, and provide scientific basis for the work of prevention. Methods Cohort study was conducted in this study. Subjects were selected to participate in the baseline survey in July 2009. A three-year follow-up was conducted for those who met the conditions. The follow-up ended in December 2012. Eventually 2177 people aged 35 to 74 that had lived in Qingdao for years were included in the study. Non-conditional Logistic regression analysis was used to calculate the advantage ratio. The population attributable risk was estimated by using the formula defined by Bruzzi. Results After controlling for confounding factors, the OR value of hyperuricemia was 1.497. The attributional risk of multifactorial population was 6.71%. Conclusion Hyperuricemia is a risk factor for diabetes, and diabetes is caused in part by a history of hyperuricemia in Qingdao.

Key words： Cohort study Diabetes Hyperuricemia Population attributable risk

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	XUE Bai GAO Ruqin LIU Li DUAN Haiping LIU Yan

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XUE Bai GAO Ruqin LIU Li DUAN Haiping LIU Yan. Analysis of the population attributable risk of hyperuricemia on people with diabetes[J]. 中国医药导报, 2018, 15(24): 42-44,54.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I24/42

[1] Skak-Nielsen H，Torp-Pedersen C，Finer N，et al. Uric acid as a risk factor for cardiovascular disease and mortality in overweight/obese individuals[J]. PLoS One，2013，8（3）：e59121.
[2] Northridge ME. Public health methods-attributable risk as a link between causality and public health action [J]. Am J Public Health，1995，85（9）：1202-1204.
[3] Lu W，Xu Y，Shao X，et al. Uric Acid Produces an Inflammatory Response through Activation of NF-κB in the Hypothalamus：Implications for the Pathogenesis of Metabolic Disorders [J]. Sci Rep，2015，5：12144.
[4] Ferrara LA，Wang H，Umans JG，et al. Serum uric acid does not predict incident metabolic syndrome in a population with high prevalence of obesity [J]. Nutr Metab Cardiovasc Dis，2014，24（12）：1360-1364.
[5] Pfister R，Barnes D，Luben R，et al. No evidence for a causal link between uric acid and type 2 diabetes：a Mendelian randomisation approach [J]. Diabetologia.，2011，54（10）：2561-2569.
[6] Li Q，Yang Z，Lu B，et al. Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes [J]. Cardiovasc Diabetol，2011，10：72.
[7] Lv Q， Meng XF， He FF，et al. High serum uric acid and increased risk of type 2 diabetes：a systemic review and meta-analysis of prospective cohort studies [J]. PLoS One，2013，8（2）：e56864.
[8] American Diabetes Association. Diagnosis and classification of diabetes [J]. AMB，1986，32(11/12)：194-196.
[9] 葛均波，徐永健．内科学[M].8版.北京：人民卫生出版社，2013：790-792.
[10] Bruzzi P，Green SB，Byar DP，et al. Estimating the population attributable risk for multiple risk factors using casecontrol data [J]. Am J Epidemiol，1985，122（5）：904-914.
[11] Kuwabara M，Kuwabara R，Hisatome I，et al. “Metabolically Healthy” Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes：5-year Japanese Cohort Study [J]. Obesity（Silver Spring），2017，25（11）：1997-2008.
[12] 李昂.血清高尿酸水平：2型糖尿病一个新的危险因素[J].中国糖尿病杂志，2010，18（1）：80.
[13] Lu W，Xu Y，Shao X，et al. Uric Acid Produces an Inflammatory Response through Activation of NF-κB in the Hypothalamus：Implications for the Pathogenesis of Metabolic Disorders [J]. Sci Rep，2015，5：12144.
[14] Billiet L，Doaty S，Katz JD，et al. Review of hyperuricemia as new marker for metabolic syndrome [J]. ISRN Rheumatol，2014，2014：852954.
[15] Perez-Pozo SE，Schold J，NakagawaT，et al. Excessive fructose intake induces the features of metabolic syndrome in healthy adult men： role of uric acid in the hypertensive response [J]. Int J Obes（Lond），2010，34（3）：454-461.
[16] Johnson RJ，Merriman T，Lanaspa MA. Causal or Noncausal Relationship of Uric Acid With Diabetes [J]. Diabetes，2015，64（8）：2720-2722.
[17] De Cosmo S，Viazzi F，Pacilli A，et al. Serum Uric Acid and Risk of CKD in Type 2 Diabetes [J]. Clin J Am Soc Nephrol，2015，10（11）：1921-1929.
[18] Fouad M，Fathy H，Zidan A. Serum uric acid and its association with hypertension，early nephropathy and chronic kidney disease in type 2 diabetic patients [J]. J Bras Nefrol，2016，38（4）：403-410.
[19] Sautin YY，Johnson RJ. Uric acid：the oxidant-antioxidant paradox [J]. Nucleosides Nucleotides Nucleic Acids，2008，27（6）：608-619.
[20] Choi HK，Ford ES. Haemoglobin A1c，fasting glucose，serum C-peptide and insulin resistance in relation to serum uric acid levels—the Third National Health and Nutrition Examination Survey [J]. Rheumatology（Oxford），2008， 47（5）：713-717.