帕金森病与褪黑素相关性的研究进展

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Abstract Parkinson′s disease is a chronic progressive neurodegenerative disease. The main clinical manifestations include motor syptoms such as bradykinesia, tremor, rigidity, and postural instability, as well as non-motor symptoms, such as impaired olfaction, sleep disorder, cognitive impairment, and emotional disorder. Melatonin is a hormone synthesized mainly by the pineal gland, regulating the circadian rhythm. Besides it acts as a free-radical scavenger, with neuroprotective, anti-inflammatory, and antioxidant properties. The unbalance of pineal melatonin synthesis disposes the body to a variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson′s disease. Parkinson′s disease is due to the impairment of melatonin concentration and the expression of its receptor in the brain. Exogenous melatonin treatment improves its motor symptoms. Besides, it also shows effects on non-motor symptoms, such as sleep disorders, congnitive disorders, anxiety and depression. The aim of this review is to summarize the knowledge about the potential role of the melatoninergic system in the pathogenesis and treatment of Parkinson′s disease.

Key words： Parkinson′s disease Melatonin Circadian rhythm Motor symptoms Non-motor symptoms Neuroprotective

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	HU Yingying WANG Xijin

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HU Yingying WANG Xijin. Study advance in the relationship between Parkinson′s disease and melatonin[J]. 中国医药导报, 2018, 15(21): 23-26.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I21/23

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