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| Systematic evaluation on the curative effect of traditional Chinese medicine combined with chemotherapy for colorectal cancer after radical operation |
| LIU Ningning MIAO Wenrong ZHU Huirong LI Qi▲ |
| Department of Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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Abstract Objective To evaluate the clinical effect of traditional Chinese medicine combined with chemotherapy in the treatment of patients with colorectal cancer after radical resection. Methods Computer was used to search various domestic and foreign medical journals published from January 1995 to January 2015, including China biomedical literature database (CBM), China national knowledge infrastructure (CNKI), Wanfang database, China scientific journal database (VIP), PubMed, ISI Web of Knowledge, Cochrane Library and important Chinese conference paper full-text database. The quality of the selected literature was determined according to the inclusion and exclusion criteria. The quality evaluation standard provided by the Cochrane manual was referenced for quality evaluation with inclusion criteria. RevMan 5.3 software was conducted for statistical analysis. Results A total of 12 articles were included in this study. The results showed that the application of traditional Chinese medicine combined with chemotherapy could improve the quality of life (QOL) (RR = 1.76, 95%CI: 1.35-2.30, P ＜ 0.0001), increase the 5-year survival rate (RR = 1.72, 95%CI: 1.18-2.49, P = 0.005); raise CD3+, CD4+ cell count, CD4+/CD8+ ratio (MD = 18.95, 95%CI: 0.09-37.82, P ＜ 0.05; MD = 5.87,95%CI: 2.25-9.49, P = 0.00; MD = 0.24, 95%CI: 0.11-0.38, P = 0.00), decrease the incidence of gastrointestinal reactions(RR = 0.51, 95%CI: 0.42-0.61, P ＜ 0.000 01), heighten the leukocyte levels (RR = 0.51, 95%CI: 0.31-0.83, P = 0.007). Conclusion Traditional Chinese medicine combined with chemotherapy can improve the long-term curative effect of radical resection of colorectal cancer, reduce the side effects of chemotherapy, improve the quality of life and promote the immunity of the patients.
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