奥沙利铂联合替吉奥治疗晚期结直肠癌的临床效果

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Abstract Objective To investigate the effects of Oxaliplatin combined with Tegafur, Gimeracil and Oteracil Potassium in the treatment of patients with advanced colorectal cancer. Methods The clinical data of 86 patients with advanced colorectal cancer admitted to Liaoning Cancer Hospital & Institute from March 2013 to January 2015 was analyzed retrospectively, and they were divided into observation group (46 cases) and control group (40 cases) according to the difference of chemotherapy regimen. The observation group was given Oxaliplatin combined with Tegafur, Gimeracil and Oteracil Potassium. The control group was given Oxaliplatin combined with Capecitabine, 21 d was as a course, both groups were treated for 6 courses. The clinical effective rate, disease control rate, long-term prognosis, the incidence of adverse reactions and the levels of tumor markers before and after treatment between the two groups were compared. Results The clinical effective rate (58.70%) and disease control rate (71.74%) in the observation group were significantly higher than those in the control group (35.00%, 50.00%) (P ＜ 0.05); Log-rank test showed that the risk of death in the observation group was significantly lower than that in the control group (χ2 = 3.952, P ＜ 0.05). The total incidence of adverse reactions (above 3 levels) in the observation group (10.87%) was significantly lower than that of the control group (27.50%) (P ＜ 0.05). After treatment, the levels of tumor markers such as carcino-embryonic antigen (CEA), alpha fetoprotein (AFP), cancer antigen 19-9 (CA19-9) and thymidine kinase 1 (TK-1) in the two groups were significantly lower than those before treatment, which of the observation group were significantly lower than those of the control group, the differences were statistically significant (P ＜ 0.05). Conclusion The efficacy and safety of Oxaliplatin combined with Tegafur, Gimeracil and Oteracil Potassium in the treatment of advanced colorectal cancer are good, which can effectively decrease the levels of tumor markers and improve the prognosis of patients.

Key words： Oxaliplatin Tegafur, Gimeracil and Oteracil Potassium Colorectal cancer Prognosis Tumor marker

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MA Tianfei TANG Yu. Clinical efficacy of Oxaliplatin combined with Tegafur, Gimeracil and Oteracil Potassium in the treatment of advanced colorectal cancer[J]. 中国医药导报, 2018, 15(17): 94-97.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I17/94

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