白细胞介素10基因启动子区-592C＞A位点多态性与宫颈癌易感性的Meta分析

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Abstract Objective To study the association between -592C＞A polymorphism within gene promoter region of interleukin-10 (IL-10) and susceptibility of cervical cancer. Methods The relevant literatures about -592C＞A polymorphism within gene promoter region of IL-10 and susceptibility of cervical cancer of PubMed, Embase, Web of SCI, CNKI and Wanfang from inception to March 2018 were searched. After the data of literatures met with inclusion criteria was extracted, taking OR value and 95% confidence interval as effect indicators, STATA 14.0 software was used to make meta analysis, and the occurrence of bias, sensibility, accumulation analysis were detected. Results Ten published studies including 3149 patients with cervical cancer and 2237 normal controls were enrolled. The results of meta analysis showed that in the total population, no significant association between IL-10 -592C＞A polymorphism and susceptibility of cervical cancer was found. After that, the subgroup analysis aiming at multiple factors showed that -592C＞A polymorphism within gene promoter region of IL-10 had significant correlation with the occurrence of cervical cancer in European (P ＜ 0.05). Conclusion The changes of -592C＞A polymorphism within IL-10 gene may increase the risk of suffering from cervical cancer in European.

Key words： Cervical cancer Interleukin-10 Polymorphism Meta analysis

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	GUO Chong1 ZHANG Zhijun2

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GUO Chong1 ZHANG Zhijun2. Association between -592C＞A polymorphism within gene promoter region of interleukin-10 and susceptibility of cervical cancer: a meta-analysis[J]. 中国医药导报, 2018, 15(17): 89-93,105.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I17/89

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