文拉法辛和艾司西酞普兰治疗抑郁症的效果及对心率变异性和自主神经功能的影响比较

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Abstract Objective To research the curative effect of Venlafaxine and Escitalopram in patients with depression and its influence on heart rate variability and autonomic nerve function. Methods From December 2016 to December 2017, 100 patients with depression admitted to Ningbo Kangning Hospital were selected and divided into Venlafaxine group and Escitalopram group by random envelope method, with 50 cases in each group. All patients were treated for 4 weeks. The Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) were applied to evaluate the clinical efficacy before and after treatment. The heart rate variability was measured by dynamic electrocardiogram. The sympathetic skin response (SSR) was used to assess the autonomic nerve function. Results After treatment, the scores of HAMD and HAMA in the two groups were all lower than those of before treatment, with statistically significant differences (P ＜ 0.05), but there were no statistically significant differences between the two groups after treatment (P ＞ 0.05). There was no statistically significant difference between the two groups in the total effective rate (P ＞ 0.05). After treatment, the standard deviation of normal to normal R wave (SDNN), standard deviation of the averages of NN intervals in all 5-minute segments of the entire recording (SDANN), total power (TP), low frequency (LF) and high frequency (HF) were all significantly higher than those of before treatment, the percentage of intervals 50 ms different from preceding interval was significantly lower than that of before treatment, and the indicators above in the Venlafaxine group improved much more remarkably, with statistically significant differences (P ＜ 0.05). After treatment, the latency of SSR in the two groups was lower than that of before treatment, the amplitude of SSR was significantly higher than that of before treatment, and the indicators above in the Venlafaxine group improved much more remarkably, with statistically significant differences (P ＜ 0.05). Conclusion Venlafaxine and Escitalopram have equivalent effects on depression. The Venlafaxine is better than Escitalopram on heart rate variability and autonomic nerve function in depression patients.

Key words： Venlafaxine Escitalopram Depression Autonomic nerve function

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	HUANG Minfang LIU Jimeng LIU Lingjiang LI Xingxing ZHOU Qi ZHOU Dongsheng

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HUANG Minfang LIU Jimeng LIU Lingjiang LI Xingxing ZHOU Qi ZHOU Dongsheng. The effect of Venlafaxine and Escitalopram in patients with depression and its influence on heart rate variability and autonomic nervous function[J]. 中国医药导报, 2018, 15(16): 130-133.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I16/130

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